Anti Protein S100-A1 (S100 Alpha) pAb (Rabbit, Affinity Purified)

Cosmo Bio LTD

Catalog No: CAC-ACC-PA002

Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

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Background
Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease have been increasing rapidly and have become a serious social problem. In recent years, new causative genes have been discovered for amyotrophic lateral sclerosis (ALS) and other intractable neurological diseases opening new avenues for research on pathogenesis. It has been suggested that aggregation and accumulation of specific proteins cause neurotoxicity and the formation of lesions, but the onset and progression mechanisms are still unclear. Neuropathological diagnostic and experimental model biomarkers are needed for drug construction, drug discovery, and therapeutic development.

The S100 protein is a low-molecular-weight, acidic and calcium binding protein that in functional form exist in dimers. S100 has two subunits: S100-alpha (94 aa; human chromosome 1) and S100-beta (92 aa; human chromosome 21) that forms as either homodimers (alpha-alpha known as S-100a(0) or beta-beta known as S-100b) or as heterodimers (known as S-100a) of ~21 kDa. S100-alpha and -beta chains show ~58% sequence identity and are both highly conserved among species. S100-alpha was originally believed to be localized to the CNS, but studies have shown it to be found in numerous tissues including cardiac, skeletal and vascular smooth muscle cells.

Applications

Western Blotting (WB): 0.1 µg/ml
Immunoprecipitation (IP) : 5 µg/ml
Enzyme-linked immunosorbent assay (ELISA): assay dependent
Immunocytochemistry (ICC) : 1:50 - 1:200
Immunofluorescence (IF): 1 µg/ml
Immunohistochemistry (Paraffin) (IHC (P)): 1 µg/ml

Product description

Package Size	50 µg
Form	Liquid (0.1M NaPB, pH7.0, 20 mg/ml BSA, 0.1% Sodium Azide (NaN3) added)
Concentration
Purity	Affinity Purified
Host	Rabbit Polyclonal
Immunogen	Purified S100-alpha protein from human pectoral muscle cells
Specificity	S100-alpha protein
Cross Reactivity	Bovine, Human, Mouse, Porcine, Rat
Subclass	IgG
Storage	Store below -20°C. Avoid freeze-thaw cycles.

References
Kato K, Haimoto H, Ariyoshi Y, Horisawa M, Washida H, Kimura S. (1985) High levels of S-100a0 (alpha alpha) protein in tumor tissues and in sera of patients with renal cell carcinoma. Jpn J Cancer Res. 76:856-62.