Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Rubicon was identified as Beclin1 interacting protein. Three distinct Beclin1 complexes exist in cells, one of the complexes including Rubicon (Beclin1, hVps34, hVps15, UVRAG, Rubicon) down regulates the process of autophagosome maturation and endocytosis.
Polyclonal Antibody of 100 µl targeting Rubicon for IP, WB.
| Product Specifications | |
| Application | IP, WB |
| Reactivity | Human |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | End Recombinant human RubiconC (722-972 aa) |
| Gene ID - Human | |
| Formulation | 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Citations for Anti-Rubicon (Human) pAb – 2 Found |
| Maejima, Yasuhiro; Kyoi, Shiori; Zhai, Peiyong; Liu, Tong; Li, Hong; Ivessa, Andreas; Sciarretta, Sebastiano; Del Re, Dominic P; Zablocki, Daniela K; Hsu, Chiao-Po; Lim, Dae-Sik; Isobe, Mitsuaki; Sadoshima, Junichi. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature Medicine. 2013;19(11):1478-88. PubMed - Comments: Used in: WB |
| Bejarano, Eloy; Yuste, Andrea; Patel, Bindi; Stout, Randy F Jr; Spray, David C; Cuervo, Ana Maria. Connexins modulate autophagosome biogenesis. Nature Cell Biology. 2014;16(5):401-14. PubMed - Comments: Used in: WB |