Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]

Catalog No:
CAC-TIP-PTD-P07
$713.00

Format: Ammonium sulfate precipitated serum (Ig fraction) in 50% glycerol with azide preservative. Prepared from fresh rabbits immunized with a peptide identical to the very popular, but sold out, CAC-TIP-PTD-PO1 that was sold as diluted serum.

Description

Product Description

TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.

These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.

Product Specifications

Product Specifications
Application WB, IHC, ELISA
Reactivity Human
Clonality Polyclonal
Host Rabbit

Documents & Links

Documents & Links for Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]
Datasheet Anti phospho TDP-43 (pS409/410) pAb Datasheet
Vendor Page Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01] at Cosmo Bio

Documents & Links for Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]
Datasheet Anti phospho TDP-43 (pS409/410) pAb Datasheet
Vendor Page Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]

Product Description

TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.

These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.

Product Specifications

Product Specifications
Application WB, IHC, ELISA
Reactivity Human
Clonality Polyclonal
Host Rabbit

Documents & Links

Documents & Links for Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]
Datasheet Anti phospho TDP-43 (pS409/410) pAb Datasheet
Vendor Page Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01] at Cosmo Bio

Documents & Links for Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]
Datasheet Anti phospho TDP-43 (pS409/410) pAb Datasheet
Vendor Page Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01]