Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.
These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.
Product Specifications | |
Application | WB, IHC, ELISA |
Reactivity | Human |
Clonality | Polyclonal |
Host | Rabbit |
Documents & Links for Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01] | |
Datasheet | Anti phospho TDP-43 (pS409/410) pAb Datasheet |
Vendor Page | Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01] at Cosmo Bio LTD |
Documents & Links for Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01] | |
Datasheet | Anti phospho TDP-43 (pS409/410) pAb Datasheet |
Vendor Page | Anti phospho TDP-43 (pS409/410) pAb [replaces CAC-TIP-PTD-P01] |