Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
| Product Specifications | |
| Application | WB, ELISA |
| Reactivity | Human |
| Clonality | Monoclonal (Clone No.: 4D12) |
| Documents & Links for Anti Phospho-SMAD2 (S250) mAb (Clone 4D12) | |
| Datasheet | Anti Phospho-SMAD2 (S250) mAb (Clone 4D12) Datasheet |
| Vendor Page | Anti Phospho-SMAD2 (S250) mAb (Clone 4D12) at CUSABIO |
| Documents & Links for Anti Phospho-SMAD2 (S250) mAb (Clone 4D12) | |
| Datasheet | Anti Phospho-SMAD2 (S250) mAb (Clone 4D12) Datasheet |
| Vendor Page | Anti Phospho-SMAD2 (S250) mAb (Clone 4D12) |