Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
| Product Specifications | |
| Application | WB, IP, ELISA |
| Reactivity | Human |
| Clonality | Monoclonal (Clone No.: 200) |
| Documents & Links for Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2) | |
| Datasheet | Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2) Datasheet |
| Vendor Page | Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2) at CUSABIO |
| Documents & Links for Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2) | |
| Datasheet | Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2) Datasheet |
| Vendor Page | Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2) |