Anti Phospho-ERN1 (S724) mAb (Clone 1F12)

CusaBio

Catalog No: CSB-RA007795A724phHU-50

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Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

Product Specifications

• Application: WB, IF, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 1F12)