Anti Phospho-EIF2S1 (S51) mAb (Clone 1C6)

CUSABIO

Catalog No: CSB-RA007523A51phHU-50

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Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Product Specifications

• Application: WB, IHC, IF, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 1C6)