Anti-p62 (SQSTM1) (Human) mAb (Clone: 5F2)

MBL

Catalog No: MBL-M162-3

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This monoclonal Antibody targets p62 for FCM, ICC, IHC, IP, WB.

Product Specifications

• Application: FC, ICC, IP, WB, IHC
• Reactivity: Human
• Clonality: Monoclonal IgG1 ĸ
• Host: Mouse
• Immunogen: Recombinant human p62 (120-440 a.a.)
• Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Citations for Anti-p62 (SQSTM1) (Human) mAb (Clone: 5F2) – 34 Found

Soll, Christopher; Jang, Jae Hwi; Riener, Marc-Oliver; Moritz, Wolfgang; Wild, Peter Johannes; Graf, Rolf; Clavien, Pierre-Alain. Serotonin promotes tumor growth in human hepatocellular cancer. Hepatology (Baltimore, Md.). 2010;51(4):1244-54. 
- Comments: Used in: WB

Fan, Weiliang; Tang, Zaiming; Chen, Dandan; Moughon, Diana; Ding, Xiaojun; Chen, She; Zhu, Muyuan; Zhong, Qing. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy. 2010;6(5):614-21. 
- Comments: Used in: WB

Wang, Bo-Shi; Liu, Yi-Zhen; Yang, Yang; Zhang, Yu; Hao, Jia-Jie; Yang, Hai; Wang, Xiao-Min; Zhang, Zi-Qiang; Zhan, Qi-Min; Wang, Ming-Rong. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clinical Science (London, England : 1979). 2013;124(3):203-14. 
- Comments: Used in: WB

Wang, Bo-Shi; Liu, Yi-Zhen; Yang, Yang; Zhang, Yu; Hao, Jia-Jie; Yang, Hai; Wang, Xiao-Min; Zhang, Zi-Qiang; Zhan, Qi-Min; Wang, Ming-Rong. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clinical Science (London, England : 1979). 2013;124(3):203-14. 
- Comments: Used in: IP

Wang, Bo-Shi; Liu, Yi-Zhen; Yang, Yang; Zhang, Yu; Hao, Jia-Jie; Yang, Hai; Wang, Xiao-Min; Zhang, Zi-Qiang; Zhan, Qi-Min; Wang, Ming-Rong. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clinical Science (London, England : 1979). 2013;124(3):203-14. 
- Comments: Used in: IHC

Rovetta, Francesca; Stacchiotti, Alessandra; Consiglio, Antonella; Cadei, Moris; Grigolato, Pier Giovanni; Lavazza, Antonio; Rezzani, Rita; Aleo, Maria Francesca. ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin. Experimental Cell Research. 2012;318(3):238-50. 
- Comments: Used in: WB

Matsumoto, Gen; Wada, Koji; Okuno, Misako; Kurosawa, Masaru; Nukina, Nobuyuki. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Molecular Cell. 2011;44(2):279-89. 
- Comments: Used in: WB

Park, Jae Myung; Huang, Shengbing; Wu, Tsung-Teh; Foster, Nathan R; Sinicrope, Frank A. Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biology & Therapy. 2013;14(2):100-7. 
- Comments: Used in: IHC

Schmeisser, Hana; Fey, Samuel B; Horowitz, Julie; Fischer, Elizabeth R; Balinsky, Corey A; Miyake, Kotaro; Bekisz, Joseph; Snow, Andrew L; Zoon, Kathryn C. Type I interferons induce autophagy in certain human cancer cell lines. Autophagy. 2013;9(5):683-96. 
- Comments: Used in: WB

Guo, X; Dong, Y; Yin, S; Zhao, C; Huo, Y; Fan, L; Hu, H. Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation. Cell Death & Disease. 2013;4(10):e822. 
- Comments: Used in: WB

Akaishi, R; Yamada, T; Nakabayashi, K; Nishihara, H; Furuta, I; Kojima, T; Morikawa, M; Yamada, T; Fujita, N; Minakami, H. Autophagy in the placenta of women with hypertensive disorders in pregnancy. Placenta. 2014;35(12):974-80. 
- Comments: Used in: ICC

Akaishi, R; Yamada, T; Nakabayashi, K; Nishihara, H; Furuta, I; Kojima, T; Morikawa, M; Yamada, T; Fujita, N; Minakami, H. Autophagy in the placenta of women with hypertensive disorders in pregnancy. Placenta. 2014;35(12):974-80. 
- Comments: Used in: IHC

Zhu, Xiaorong; Messer, Jeannette S; Wang, Yunwei; Lin, Fanfei; Cham, Candace M; Chang, Jonathan; Billiar, Timothy R; Lotze, Michael T; Boone, David L; Chang, Eugene B. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. The Journal Of Clinical Investigation. 2015;125(3):1098-110. 
- Comments: Used in: WB

Janda, Elzbieta; Lascala, Antonella; Carresi, Cristina; Parafati, Maddalena; Aprigliano, Serafina; Russo, Vanessa; Savoia, Claudia; Ziviani, Elena; Musolino, Vincenzo; Morani, Federica; Isidoro, Ciro; Mollace, Vincenzo. Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection. Autophagy. 11(7):1063-80. 
- Comments: Used in: WB

Janda, Elzbieta; Lascala, Antonella; Carresi, Cristina; Parafati, Maddalena; Aprigliano, Serafina; Russo, Vanessa; Savoia, Claudia; Ziviani, Elena; Musolino, Vincenzo; Morani, Federica; Isidoro, Ciro; Mollace, Vincenzo. Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection. Autophagy. 11(7):1063-80. 
- Comments: Used in: ICC

Stolz, Alexandra; Putyrski, Mateusz; Kutle, Ivana; Huber, Jessica; Wang, Chunxin; Major, Viktória; Sidhu, Sachdev S; Youle, Richard J; Rogov, Vladimir V; Dötsch, Volker; Ernst, Andreas; Dikic, Ivan. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. The Embo Journal. 2017;36(4):549-564. 
- Comments: Used in: WB

Sakamoto, Shuichiro; Miyara, Masatsugu; Sanoh, Seigo; Ohta, Shigeru; Kotake, Yaichiro. Mild MPP(+) exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation. Scientific Reports. 2017;7:46668. 
- Comments: Used in: WB

Wacker, Rahel; Eickel, Nina; Schmuckli-Maurer, Jacqueline; Annoura, Takeshi; Niklaus, Livia; Khan, Shahid M; Guan, Jun-Lin; Heussler, Volker T. LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway. Cellular Microbiology. 2017;19(10) 
- Comments: Used in: WB

Bingel, Corinna; Koeneke, Emily; Ridinger, Johannes; Bittmann, Annika; Sill, Martin; Peterziel, Heike; Wrobel, Jagoda K; Rettig, Inga; Milde, Till; Fernekorn, Uta; Weise, Frank; Schober, Andreas; Witt, Olaf; Oehme, Ina. Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance. Cell Death & Disease. 2017;8(8):e3013. 
- Comments: Used in: WB

Schmuckli-Maurer, Jacqueline; Reber, Vera; Wacker, Rahel; Bindschedler, Annina; Zakher, Anthony; Heussler, Volker Theo. Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane. Plos One. 12(8):e0183797. 
- Comments: Used in: WB

Schmuckli-Maurer, Jacqueline; Reber, Vera; Wacker, Rahel; Bindschedler, Annina; Zakher, Anthony; Heussler, Volker Theo. Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane. Plos One. 12(8):e0183797. 
- Comments: Used in: ICC

Zhao, Qiong; Hu, Zhan-Ying; Zhang, Jing-Pu; Jiang, Jian-Dong; Ma, Yuan-Yuan; Li, Jian-Rui; Peng, Zong-Gen; Chen, Jin-Hua. Dual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity. Scientific Reports. 2017;7(1):11250. 
- Comments: Used in: ICC

Doerflinger, Sylvie Y; Cortese, Mirko; Romero-Brey, Inés; Menne, Zach; Tubiana, Thibault; Schenk, Christian; White, Peter A; Bartenschlager, Ralf; Bressanelli, Stéphane; Hansman, Grant S; Lohmann, Volker. Membrane alterations induced by nonstructural proteins of human norovirus. Plos Pathogens. 2017;13(10):e1006705. 
- Comments: Used in: ICC

Lötzerich, Mark; Roulin, Pascal S; Boucke, Karin; Witte, Robert; Georgiev, Oleg; Greber, Urs F. Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. Cell Death & Disease. 2018;9(3):272. 
- Comments: Used in: WB

Sun, Yan; Huang, Yong-Hao; Huang, Feng-Ying; Mei, Wen-Li; Liu, Quan; Wang, Cai-Chun; Lin, Ying-Ying; Huang, Canhua; Li, Yue-Nan; Dai, Hao-Fu; Tan, Guang-Hong. 3'-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells. Theranostics. 8(7):2044-2060. 
- Comments: Used in: WB

Kanda, Ranka; Hiraike, Haruko; Wada-Hiraike, Osamu; Ichinose, Takayuki; Nagasaka, Kazunori; Sasajima, Yuko; Ryo, Eiji; Fujii, Tomoyuki; Osuga, Yutaka; Ayabe, Takuya. Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer. Bmc Cancer. 2018;18(1):657. 
- Comments: Used in: WB

Qiu, Jingping; Li, Xiaoting; He, Yingjian; Sun, Dan; Li, Wenhui; Xin, Yan. Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. Journal Of Cancer Research And Clinical Oncology. 2018;144(10):1869-1886. 
- Comments: Used in: WB

Mori, Hiroyuki; Fukuhara, Takasuke; Ono, Chikako; Tamura, Tomokazu; Sato, Asuka; Fauzyah, Yuzy; Wada, Masami; Okamoto, Toru; Noda, Takeshi; Yoshimori, Tamotsu; Matsuura, Yoshiharu. Induction of selective autophagy in cells replicating hepatitis C virus genome. The Journal Of General Virology. 2018;99(12):1643-1657. 
- Comments: Used in: WB

Nakashima, Akitoshi; Cheng, Shi-Bin; Kusabiraki, Tae; Motomura, Kenichiro; Aoki, Aiko; Ushijima, Akemi; Ono, Yosuke; Tsuda, Sayaka; Shima, Tomoko; Yoshino, Osamu; Sago, Haruhiko; Matsumoto, Kenji; Sharma, Surendra; Saito, Shigeru. Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts. Scientific Reports. 2019;9(1):11466. 
- Comments: Used in: ICC

Nakashima, Akitoshi; Cheng, Shi-Bin; Kusabiraki, Tae; Motomura, Kenichiro; Aoki, Aiko; Ushijima, Akemi; Ono, Yosuke; Tsuda, Sayaka; Shima, Tomoko; Yoshino, Osamu; Sago, Haruhiko; Matsumoto, Kenji; Sharma, Surendra; Saito, Shigeru. Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts. Scientific Reports. 2019;9(1):11466. 
- Comments: Used in: WB

Gao, Likun; Wang, Zhi; Lu, Danhua; Huang, Jinling; Liu, Jin; Hong, Li. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death & Disease. 2019;10(8):609. 
- Comments: Used in: WB

Gao, Likun; Wang, Zhi; Lu, Danhua; Huang, Jinling; Liu, Jin; Hong, Li. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death & Disease. 2019;10(8):609. 
- Comments: Used in: IHC

Li, Suting; Hao, Menglei; Li, Bingshu; Chen, Mao; Chen, Jue; Tang, Jianming; Hong, Shasha; Min, Jie; Hu, Ming; Hong, Li. CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade. Cell Death & Disease. 2020;11(4):279. 
- Comments: Used in: WB

Yamamuro, Tadashi; Kawabata, Tsuyoshi; Fukuhara, Atsunori; Saita, Shotaro; Nakamura, Shuhei; Takeshita, Hikari; Fujiwara, Mari; Enokidani, Yusuke; Yoshida, Gota; Tabata, Keisuke; Hamasaki, Maho; Kuma, Akiko; Yamamoto, Koichi; Shimomura, Iichiro; Yoshimori, Tamotsu. Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nature Communications. 2020;11(1):4150. 
- Comments: Used in: WB