Application: WB, FC, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
| Documents & Links for Anti NR3C1 mAb (Clone 2D8) | |
| Datasheet | Anti NR3C1 mAb (Clone 2D8) Datasheet |
| Vendor Page | Anti NR3C1 mAb (Clone 2D8) at CUSABIO |
| Documents & Links for Anti NR3C1 mAb (Clone 2D8) | |
| Datasheet | Anti NR3C1 mAb (Clone 2D8) Datasheet |
| Vendor Page | Anti NR3C1 mAb (Clone 2D8) |
