Application: IHC, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
| Documents & Links for Anti NPC1L1 mAb (Clone 4B10) | |
| Datasheet | Anti NPC1L1 mAb (Clone 4B10) Datasheet |
| Vendor Page | Anti NPC1L1 mAb (Clone 4B10) at CUSABIO |
| Documents & Links for Anti NPC1L1 mAb (Clone 4B10) | |
| Datasheet | Anti NPC1L1 mAb (Clone 4B10) Datasheet |
| Vendor Page | Anti NPC1L1 mAb (Clone 4B10) |
