Anti NPC1L1 mAb (Clone 4B10)

CUSABIO

Catalog No: CSB-RA921474A0HU-50

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Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.

Product Specifications

• Application: IHC, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 4B10)