May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.
| Product Specifications |
| Application |
IHC, IF, ELISA |
| Reactivity |
Human |
| Clonality |
Monoclonal (Clone No.: 3A1) |
