Anti Monocarboxylate transporter 2 (MCT2) pAb (Rabbit, Antiserum)

Cosmo Bio LTD

Catalog No: CAC-YCU-M-MCT2A

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Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

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A transport protein (variously referred to as a transmembrane pump, transporter, escort protein, acid transport protein, cation transport protein, or anion transport protein) is a protein that serves the function of moving other materials within an organism. Transport proteins are vital to the growth and life of all living things. There are several different kinds of transport proteins. Carrier proteins are proteins involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane.[1] Carrier proteins are integral membrane proteins; that is, they exist within and span the membrane across which they transport substances. The proteins may assist in the movement of substances by facilitated diffusion (i.e., passive transport) or active transport. These mechanisms of movement are known as carrier-mediated transport.[2] Each carrier protein is designed to recognize only one substance or one group of very similar substances. Research has correlated defects in specific carrier proteins with specific diseases.[3] A membrane transport protein (or simply transporter) is a membrane protein[4] that acts as such a carrier. [from: Wikipedia contributors. (2019, May 9). Transport protein. In Wikipedia, The Free Encyclopedia. Retrieved 18:43, June 6, 2019, from https://en.wikipedia.org/w/index.php?title=Transport_protein&oldid=896329420]

MCT2 is a proton-coupled monocarboxylate transporter is encoded in humans by the SLC16A7 gene.[5] It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter. Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform. Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate.[6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.[7] [from: Wikipedia contributors. (2019, April 20). Monocarboxylate transporter 2. In Wikipedia, The Free Encyclopedia. Retrieved 18:41, June 6, 2019, from https://en.wikipedia.org/w/index.php?title=Monocarboxylate_transporter_2&oldid=893305296]

References:
1) Watanabe-Kaneko K, et al. (2007) The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2. Neuroreport. 18(5):489-493.