Application: WB, IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: microphthalmia-associated transcription factor
Gene Name: MITF
Alternative Gene Name: bHLHe32, MI, WS2, WS2A
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000035158: 88%, ENSRNOG00000008658: 87%
Entrez Gene ID: 4286
Uniprot ID: O75030
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: microphthalmia-associated transcription factor
Gene Name: MITF
Alternative Gene Name: bHLHe32, MI, WS2, WS2A
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000035158: 88%, ENSRNOG00000008658: 87%
Entrez Gene ID: 4286
Uniprot ID: O75030
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti MITF pAb (ATL-HPA003259 w/enhanced validation) | |
| Antigen | PrEST Antigen MITF (ATL-APrEST84788) |
| Documents & Links for Anti MITF pAb (ATL-HPA003259 w/enhanced validation) | |
| Datasheet | Anti MITF pAb (ATL-HPA003259 w/enhanced validation) Datasheet (External Link) |
| Vendor Page | Anti MITF pAb (ATL-HPA003259 w/enhanced validation) at Atlas |
| Documents & Links for Anti MITF pAb (ATL-HPA003259 w/enhanced validation) | |
| Datasheet | Anti MITF pAb (ATL-HPA003259 w/enhanced validation) Datasheet (External Link) |
| Vendor Page | Anti MITF pAb (ATL-HPA003259 w/enhanced validation) |
| Citations for Anti MITF pAb (ATL-HPA003259 w/enhanced validation) – 15 Found |
| Lysosomal adaptation: How cells respond to lysosomotropic compounds. PLoS One. 2017 Mar 16;12(3):e0173771. doi: 10.1371/journal.pone.0173771. eCollection 2017. PubMed |
| BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling. Biol Open. 2017 Jul 15;6(7):979-992. doi: 10.1242/bio.018739. PubMed |
| BRN2 is a non-canonical melanoma tumor-suppressor. Nat Commun. 2021 Jun 17;12(1):3707. doi: 10.1038/s41467-021-23973-5. PubMed |
| Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma. J Exp Med. 2021 Sep 6;218(9):e20210571. doi: 10.1084/jem.20210571. Epub 2021 Jul 21. PubMed |
| MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells. Commun Biol. 2022 Jan 28;5(1):101. doi: 10.1038/s42003-022-03049-w. PubMed |
| Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition. Genome Res. 2014 May;24(5):751-60. doi: 10.1101/gr.166231.113. Epub 2014 Jan 17. PubMed |
| MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015 Nov 4;6:8755. doi: 10.1038/ncomms9755. PubMed |
| A direct link between MITF, innate immunity, and hair graying. PLoS Biol. 2018 May 3;16(5):e2003648. doi: 10.1371/journal.pbio.2003648. eCollection 2018 May. PubMed |
| MITF controls the TCA cycle to modulate the melanoma hypoxia response. Pigment Cell Melanoma Res. 2019 Nov;32(6):792-808. doi: 10.1111/pcmr.12802. Epub 2019 Jul 8. PubMed |
| Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles. Sci Adv. 2019 Dec 4;5(12):eaax5208. doi: 10.1126/sciadv.aax5208. eCollection 2019 Dec. PubMed |
| The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor. PLoS Genet. 2019 Dec 27;15(12):e1008501. doi: 10.1371/journal.pgen.1008501. eCollection 2019 Dec. PubMed |
| PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Dev Cell. 2020 Aug 10;54(3):317-332.e9. doi: 10.1016/j.devcel.2020.06.013. Epub 2020 Jul 10. PubMed |
| MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61. Oncogene. 2021 Jan;40(1):112-126. doi: 10.1038/s41388-020-01504-8. Epub 2020 Oct 20. PubMed |
| Classification and Grading of Melanocytic Lesions in a Mouse Model of NRAS-driven Melanomagenesis. J Histochem Cytochem. 2021 Mar;69(3):203-218. doi: 10.1369/0022155420977970. Epub 2020 Dec 7. PubMed |
| MITF reprograms the extracellular matrix and focal adhesion in melanoma. Elife. 2021 Jan 13;10:e63093. doi: 10.7554/eLife.63093. PubMed |