Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, Metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.
| Product Specifications |
| Application |
WB, IHC, ELISA, IP |
| Reactivity |
Human |
| Clonality |
Polyclonal |
| Host |
Rabbit |
