Application: WB, FC, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human, Rat
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human, Rat
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
| Documents & Links for Anti LGR5 mAb (Clone 4H8) | |
| Datasheet | Anti LGR5 mAb (Clone 4H8) Datasheet |
| Vendor Page | Anti LGR5 mAb (Clone 4H8) at CUSABIO |
| Documents & Links for Anti LGR5 mAb (Clone 4H8) | |
| Datasheet | Anti LGR5 mAb (Clone 4H8) Datasheet |
| Vendor Page | Anti LGR5 mAb (Clone 4H8) |
