This LC3 monoclonal antibody of 20 µL is validated for multiple applications (FCM, IC, IH, IP, WB) and has over 25 citations.
More information about LC3 and autophagy can be found in our Blog. In addition you may download our Autophagy Pathway Poster.
| Product Specifications | |
| Application | FC, ICC, IP, IHC |
| Reactivity | Human, Mouse, Rat, Hamster |
| Clonality | Monoclonal IgG1 κ |
| Host | Mouse |
| Immunogen | Recombinant Human LC3 (MAP1LC3B: 1-120 a.a.) |
| Formulation | 40 µg IgG in 20 µL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Citations for Anti-LC3 mAb for My select sampler set (Clone: 4E12) – 14 Found |
| Ho, Hsiang; Kapadia, Rubina; Al-Tahan, Sejad; Ahmad, Safoora; Ganesan, Anand K. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. The Journal Of Biological Chemistry. 2011;286(14):12509-23. PubMed - Comments: Used in: WB |
| Saiki, Shinji; Sasazawa, Yukiko; Imamichi, Yoko; Kawajiri, Sumihiro; Fujimaki, Takahiro; Tanida, Isei; Kobayashi, Hiroki; Sato, Fumiaki; Sato, Shigeto; Ishikawa, Ken-Ichi; Imoto, Masaya; Hattori, Nobutaka. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy. 2011;7(2):176-87. PubMed - Comments: Used in: WB |
| Kasai, Michiyuki; Tanida, Isei; Ueno, Takashi; Kominami, Eiki; Seki, Sachiko; Ikeda, Tohru; Mizuochi, Toshiaki. Autophagic compartments gain access to the MHC class II compartments in thymic epithelium. Journal Of Immunology (Baltimore, Md. : 1950). 2009;183(11):7278-85. PubMed - Comments: Used in: WB |
| Kasai, Michiyuki; Tanida, Isei; Ueno, Takashi; Kominami, Eiki; Seki, Sachiko; Ikeda, Tohru; Mizuochi, Toshiaki. Autophagic compartments gain access to the MHC class II compartments in thymic epithelium. Journal Of Immunology (Baltimore, Md. : 1950). 2009;183(11):7278-85. PubMed - Comments: Used in: ICC |
| Kasai, Michiyuki; Tanida, Isei; Ueno, Takashi; Kominami, Eiki; Seki, Sachiko; Ikeda, Tohru; Mizuochi, Toshiaki. Autophagic compartments gain access to the MHC class II compartments in thymic epithelium. Journal Of Immunology (Baltimore, Md. : 1950). 2009;183(11):7278-85. PubMed - Comments: Used in: IHC |
| Mookerjee, Shona; Papanikolaou, Theodora; Guyenet, Stephan J; Sampath, Vanitha; Lin, Amy; Vitelli, Cathy; DeGiacomo, Francesco; Sopher, Bryce L; Chen, Sylvia F; La Spada, Albert R; Ellerby, Lisa M. Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2009;29(48):15134-44. PubMed - Comments: Used in: IP |
| Mookerjee, Shona; Papanikolaou, Theodora; Guyenet, Stephan J; Sampath, Vanitha; Lin, Amy; Vitelli, Cathy; DeGiacomo, Francesco; Sopher, Bryce L; Chen, Sylvia F; La Spada, Albert R; Ellerby, Lisa M. Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2009;29(48):15134-44. PubMed - Comments: Used in: IHC |
| Nishitsuji, Kazuchika; Tomiyama, Takami; Ishibashi, Kenichi; Ito, Kazuhiro; Teraoka, Rie; Lambert, Mary P; Klein, William L; Mori, Hiroshi. The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. The American Journal Of Pathology. 2009;174(3):957-69. PubMed - Comments: Used in: ICC |
| Wang, Yongjun; Singh, Rajat; Massey, Ashish C; Kane, Saul S; Kaushik, Susmita; Grant, Taneisha; Xiang, Youqing; Cuervo, Ana Maria; Czaja, Mark J. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. The Journal Of Biological Chemistry. 2008;283(8):4766-77. PubMed - Comments: Used in: WB |
| Wang, Yongjun; Singh, Rajat; Massey, Ashish C; Kane, Saul S; Kaushik, Susmita; Grant, Taneisha; Xiang, Youqing; Cuervo, Ana Maria; Czaja, Mark J. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. The Journal Of Biological Chemistry. 2008;283(8):4766-77. PubMed - Comments: Used in: ICC |
| Chalazonitis, Alcmène; Tang, Amy A; Shang, Yulei; Pham, Tuan D; Hsieh, Ivy; Setlik, Wanda; Gershon, Michael D; Huang, Eric J. Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2011;31(39):13746-57. PubMed - Comments: Used in: ICC |
| Murthy, Aditya; Li, Yun; Peng, Ivan; Reichelt, Mike; Katakam, Anand Kumar; Noubade, Rajkumar; Roose-Girma, Merone; DeVoss, Jason; Diehl, Lauri; Graham, Robert R; van Lookeren Campagne, Menno. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature. 2014;506(7489):456-62. PubMed - Comments: Used in: WB |
| Murthy, Aditya; Li, Yun; Peng, Ivan; Reichelt, Mike; Katakam, Anand Kumar; Noubade, Rajkumar; Roose-Girma, Merone; DeVoss, Jason; Diehl, Lauri; Graham, Robert R; van Lookeren Campagne, Menno. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature. 2014;506(7489):456-62. PubMed |
| Mori, Hiroyuki; Fukuhara, Takasuke; Ono, Chikako; Tamura, Tomokazu; Sato, Asuka; Fauzyah, Yuzy; Wada, Masami; Okamoto, Toru; Noda, Takeshi; Yoshimori, Tamotsu; Matsuura, Yoshiharu. Induction of selective autophagy in cells replicating hepatitis C virus genome. The Journal Of General Virology. 2018;99(12):1643-1657. PubMed - Comments: Used in: ICC |