Anti-LC3 (Human) mAb (Clone: 8E10)

MBL

Catalog No: MBL-M186-3

Browse all MBL products from our MBL products homepage.

Monoclonal Antibody of 100 µl targeting LC3 for WB.

Product Specifications

• Application: WB
• Reactivity: Human, Mouse, Rat, Hamster
• Clonality: Monoclonal IgG2a ĸ
• Host: Mouse
• Immunogen: Human LC3 (MAP1LC3B), 1-120 aa (recombinant)
• Gene ID - Human:

  81631

• Gene ID - Mouse:

  67443

• Gene ID - Rat:

  64862

• Formulation: 1 mg/mL in PBS containing 50% Glycerol (pH 7.2). No preservative is contained.

Citations for Anti-LC3 (Human) mAb (Clone: 8E10) – 32 Found

Margariti, Andriana; Li, Hongling; Chen, Ting; Martin, Daniel; Vizcay-Barrena, Gema; Alam, Saydul; Karamariti, Eirini; Xiao, Qingzhong; Zampetaki, Anna; Zhang, Zhongyi; Wang, Wen; Jiang, Zhixin; Gao, Chan; Ma, Benyu; Chen, Ye-Guang; Cockerill, Gillian; Hu, Yanhua; Xu, Qingbo; Zeng, Lingfang. XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. The Journal Of Biological Chemistry. 2013;288(2):859-72. 
- Comments: Used in: WB

Mukai, R; Ohshima, T. HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm. Oncogene. 2014;33(18):2317-28. 
- Comments: Used in: WB

Maejima, Yasuhiro; Kyoi, Shiori; Zhai, Peiyong; Liu, Tong; Li, Hong; Ivessa, Andreas; Sciarretta, Sebastiano; Del Re, Dominic P; Zablocki, Daniela K; Hsu, Chiao-Po; Lim, Dae-Sik; Isobe, Mitsuaki; Sadoshima, Junichi. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature Medicine. 2013;19(11):1478-88. 
- Comments: Used in: WB

Wang, Meng; Kern, Ashley M; Hülskötter, Marieke; Greninger, Patricia; Singh, Anurag; Pan, Yunfeng; Chowdhury, Dipanjan; Krause, Mechthild; Baumann, Michael; Benes, Cyril H; Efstathiou, Jason A; Settleman, Jeff; Willers, Henning. EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Research. 2014;74(10):2825-34. 
- Comments: Used in: WB

He, Ruina; Peng, Jingyu; Yuan, Pengfei; Xu, Fang; Wei, Wensheng. Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy. 11(5):740-7. 
- Comments: Used in: WB

Hasegawa, Koichi; Yasuda, Toru; Shiraishi, Chinatsu; Fujiwara, Kazushiro; Przedborski, Serge; Mochizuki, Hideki; Yoshikawa, Kazuaki. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nature Communications. 2016;7:10943. 
- Comments: Used in: WB

Li, Zhiyuan; Ji, Xinmiao; Wang, Wenchao; Liu, Juanjuan; Liang, Xiaofei; Wu, Hong; Liu, Jing; Eggert, Ulrike S; Liu, Qingsong; Zhang, Xin. Ammonia Induces Autophagy through Dopamine Receptor D3 and MTOR. Plos One. 11(4):e0153526. 
- Comments: Used in: WB

Li, Zhiyuan; Ji, Xinmiao; Wang, Wenchao; Liu, Juanjuan; Liang, Xiaofei; Wu, Hong; Liu, Jing; Eggert, Ulrike S; Liu, Qingsong; Zhang, Xin. Ammonia Induces Autophagy through Dopamine Receptor D3 and MTOR. Plos One. 11(4):e0153526. 
- Comments: Used in: ICC

Nakanishi, Tsukasa; Song, Yuan; He, Cuiying; Wang, Duo; Morita, Kentaro; Tsukada, Junichi; Kanazawa, Tamotsu; Yoshida, Yasuhiro. Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia. Peerj. 4:e2026. 
- Comments: Used in: WB

Boada-Romero, Emilio; Serramito-Gómez, Inmaculada; Sacristán, María P; Boone, David L; Xavier, Ramnik J; Pimentel-Muiños, Felipe X. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nature Communications. 2016;7:11821. 
- Comments: Used in: WB

Sasaki, Natsuki; Nakamura, Masayuki; Kodama, Akiko; Urata, Yuka; Shiokawa, Nari; Hayashi, Takehiro; Sano, Akira. Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells. Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology. 2016;30(11):3726-3732. 
- Comments: Used in: WB

Maueröder, Christian; Schall, Nicolas; Meyer, Frédéric; Mahajan, Aparna; Garnier, Benjamin; Hahn, Jonas; Kienhöfer, Deborah; Hoffmann, Markus H; Muller, Sylviane. Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide. Frontiers In Immunology. 8:16. 
- Comments: Used in: WB

Zhao, Zhiwei; Li, Xiaoling; Li, Qing. Curcumin accelerates the repair of sciatic nerve injury in rats through reducing Schwann cells apoptosis and promoting myelinization. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2017;92:1103-1110. 
- Comments: Used in: WB

He, Ruina; Peng, Jingyu; Yuan, Pengfei; Yang, Junjiao; Wu, Xiaoji; Wang, Yinan; Wei, Wensheng. Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. Scientific Reports. 2017;7(1):10532. 
- Comments: Used in: WB

Meng, Xiang-Hui; Chen, Bo; Zhang, Jing-Pu. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. International Journal Of Biological Sciences. 13(8):985-995. 
- Comments: Used in: IP

Meng, Xiang-Hui; Chen, Bo; Zhang, Jing-Pu. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. International Journal Of Biological Sciences. 13(8):985-995. 
- Comments: Used in: ICC

Sun, Yong; Byon, Chang Hyun; Yang, Youfeng; Bradley, Wayne E; Dell'Italia, Louis J; Sanders, Paul W; Agarwal, Anupam; Wu, Hui; Chen, Yabing. Dietary potassium regulates vascular calcification and arterial stiffness. Jci Insight. 2017;2(19) 
- Comments: Used in: WB

Wang, Hui; Jiang, Tianyue; Li, Wei; Gao, Na; Zhang, Tao. Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer's disease. Toxicology Letters. 2018;282:100-108. 
- Comments: Used in: WB

Li, Wen; Li, Kai; Gao, Jing; Yang, Zhuo. Autophagy is required for human umbilical cord mesenchymal stem cells to improve spatial working memory in APP/PS1 transgenic mouse model. Stem Cell Research & Therapy. 2018;9(1):9. 
- Comments: Used in: ICC

Wang, Yan; Wang, Hui; Ge, Hui; Yang, Zhuo. AG-1031 induced autophagic cell death and apoptosis in C6 glioma cells associated with Notch-1 signaling pathway. Journal Of Cellular Biochemistry. 2018;119(7):5893-5903. 
- Comments: Used in: WB

Li, Yu-Chen; Zhang, Miao-Qing; Zhang, Jing-Pu. Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish. Frontiers In Cellular And Infection Microbiology. 8:109. 
- Comments: Used in: WB

Li, Yu-Chen; Zhang, Miao-Qing; Zhang, Jing-Pu. Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish. Frontiers In Cellular And Infection Microbiology. 8:109. 
- Comments: Used in: WB

Taniguchi, Keiko; Matsumura, Kengo; Ii, Hiromi; Kageyama, Susumu; Ashihara, Eishi; Chano, Tokuhiro; Kawauchi, Akihiro; Yoshiki, Tatsuhiro; Nakata, Susumu. Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. American Journal Of Cancer Research. 8(4):650-661. 
- Comments: Used in: WB

Kozako, Tomohiro; Mellini, Paolo; Ohsugi, Takeo; Aikawa, Akiyoshi; Uchida, Yu-Ichiro; Honda, Shin-Ichiro; Suzuki, Takayoshi. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. Bmc Cancer. 2018;18(1):791. 
- Comments: Used in: WB

Saito, Toshiro; Nah, Jihoon; Oka, Shin-Ichi; Mukai, Risa; Monden, Yoshiya; Maejima, Yasuhiro; Ikeda, Yoshiyuki; Sciarretta, Sebastiano; Liu, Tong; Li, Hong; Baljinnyam, Erdene; Fraidenraich, Diego; Fritzky, Luke; Zhai, Peiyong; Ichinose, Shizuko; Isobe, Mitsuaki; Hsu, Chiao-Po; Kundu, Mondira; Sadoshima, Junichi. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. The Journal Of Clinical Investigation. 2019;129(2):802-819. 
- Comments: Used in: WB

Slowicka, Karolina; Serramito-Gómez, Inmaculada; Boada-Romero, Emilio; Martens, Arne; Sze, Mozes; Petta, Ioanna; Vikkula, Hanna K; De Rycke, Riet; Parthoens, Eef; Lippens, Saskia; Savvides, Savvas N; Wullaert, Andy; Vereecke, Lars; Pimentel-Muiños, Felipe X; van Loo, Geert. Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis. Nature Communications. 2019;10(1):1834. 
- Comments: Used in: WB

Kokubu, Yuko; Nagino, Tomoko; Sasa, Katsunori; Oikawa, Tatsuo; Miyake, Katsuya; Kume, Akiko; Fukuda, Mikiko; Fuse, Hiromitsu; Tozawa, Ryuichi; Sakurai, Hidetoshi. Phenotypic Drug Screening for Dysferlinopathy Using Patient-Derived Induced Pluripotent Stem Cells. Stem Cells Translational Medicine. 2019;8(10):1017-1029. 
- Comments: Used in: WB

Ma, Yuan-Yuan; Li, Jian-Rui; Peng, Zong-Gen; Zhang, Jing-Pu. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Cell Death & Disease. 2020;11(3):200. 
- Comments: Used in: WB

Ma, Yuan-Yuan; Li, Jian-Rui; Peng, Zong-Gen; Zhang, Jing-Pu. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Cell Death & Disease. 2020;11(3):200. 
- Comments: Used in: IF

Yamamoto, Yo-Hei; Kasai, Ayano; Omori, Hiroko; Takino, Tomoe; Sugihara, Munechika; Umemoto, Tetsuo; Hamasaki, Maho; Hatta, Tomohisa; Natsume, Tohru; Morimoto, Richard I; Arai, Ritsuko; Waguri, Satoshi; Sato, Miyuki; Sato, Ken; Bar-Nun, Shoshana; Yoshimori, Tamotsu; Noda, Takeshi; Nagata, Kazuhiro. ERdj8 governs the size of autophagosomes during the formation process. The Journal Of Cell Biology. 2020;219(8) 
- Comments: Used in: WB

Yamamoto, Yo-Hei; Kasai, Ayano; Omori, Hiroko; Takino, Tomoe; Sugihara, Munechika; Umemoto, Tetsuo; Hamasaki, Maho; Hatta, Tomohisa; Natsume, Tohru; Morimoto, Richard I; Arai, Ritsuko; Waguri, Satoshi; Sato, Miyuki; Sato, Ken; Bar-Nun, Shoshana; Yoshimori, Tamotsu; Noda, Takeshi; Nagata, Kazuhiro. ERdj8 governs the size of autophagosomes during the formation process. The Journal Of Cell Biology. 2020;219(8) 
- Comments: Used in: ICC

Serramito-Gómez, Inmaculada; Boada-Romero, Emilio; Villamuera, Raquel; Fernández-Cabrera, Álvaro; Cedillo, José Luis; Martín-Regalado, Ángela; Carding, Simon; Mayer, Uli; Powell, Penny P; Wileman, Thomas; García-Higuera, Irene; Pimentel-Muiños, Felipe X. Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain. Nature Communications. 2020;11(1):5919. 
- Comments: Used in: IP