Application: ICC, IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: lysine (K)-specific methyltransferase 2D
Gene Name: KMT2D
Alternative Gene Name: ALR, CAGL114, MLL2, MLL4, TNRC21
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000048154: 90%, ENSRNOG00000061499: 84%
Entrez Gene ID: 8085
Uniprot ID: O14686
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: lysine (K)-specific methyltransferase 2D
Gene Name: KMT2D
Alternative Gene Name: ALR, CAGL114, MLL2, MLL4, TNRC21
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000048154: 90%, ENSRNOG00000061499: 84%
Entrez Gene ID: 8085
Uniprot ID: O14686
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti KMT2D pAb (ATL-HPA035977) | |
| Antigen | PrEST Antigen KMT2D (ATL-APrEST86867) |
| Documents & Links for Anti KMT2D pAb (ATL-HPA035977) | |
| Datasheet | Anti KMT2D pAb (ATL-HPA035977) Datasheet (External Link) |
| Vendor Page | Anti KMT2D pAb (ATL-HPA035977) at Atlas |
| Documents & Links for Anti KMT2D pAb (ATL-HPA035977) | |
| Datasheet | Anti KMT2D pAb (ATL-HPA035977) Datasheet (External Link) |
| Vendor Page | Anti KMT2D pAb (ATL-HPA035977) |
| Citations for Anti KMT2D pAb (ATL-HPA035977) – 10 Found |
| KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis. Genes Dev. 2018 Jan 15;32(2):181-193. doi: 10.1101/gad.306241.117. Epub 2018 Feb 12. PubMed |
| PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression. Cell Rep. 2019 Apr 2;27(1):294-306.e5. doi: 10.1016/j.celrep.2019.02.111. PubMed |
| Genomic Analyses of Metaplastic or Sarcomatoid Carcinomas From Different Organs Revealed Frequent Mutations in KMT2D. Front Mol Biosci. 2021 Jul 15;8:688692. doi: 10.3389/fmolb.2021.688692. eCollection 2021. PubMed |
| MLL4 mediates differentiation and tumor suppression through ferroptosis. Sci Adv. 2021 Dec 10;7(50):eabj9141. doi: 10.1126/sciadv.abj9141. Epub 2021 Dec 10. PubMed |
| Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol. 2013 Mar;125(3):373-84. doi: 10.1007/s00401-012-1070-9. Epub 2012 Nov 25. PubMed |
| Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nat Med. 2015 Oct;21(10):1190-8. doi: 10.1038/nm.3940. Epub 2015 Sep 14. PubMed |
| KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary. Nat Commun. 2018 Jun 27;9(1):2496. doi: 10.1038/s41467-018-04950-x. PubMed |
| Low MLL2 Protein Expression Is Associated With Fibrosis in Early Stage Gastric Cancer. In Vivo. 2021 Jan-Feb;35(1):603-609. doi: 10.21873/invivo.12297. PubMed |
| Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth. EMBO Rep. 2021 Jun 4;22(6):e50600. doi: 10.15252/embr.202050600. Epub 2021 Apr 16. PubMed |
| Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer. Transl Cancer Res. 2022 Aug;11(8):2607-2621. doi: 10.21037/tcr-22-431. PubMed |