Anti Klotho mAb (Clone KM2119)

Cosmo Bio

Catalog No: KAL-KO604

Product Description

Gene Symbol: KL

Gene ID: 9365

Concentration: 0.25mg/mL

Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may beinactive as aglycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Product Specifications

• Application: IHC, WB
• Reactivity: Mouse, Human
• Clonality: Monoclonal (Clone No.: KM2119)
• Host: Rat

Citations

Citations for Anti Klotho mAb (Clone KM2119) – 1 Found

Xiao, Zhousheng; Riccardi, Demian; Velazquez, Hector A; Chin, Ai L; Yates, Charles R; Carrick, Jesse D; Smith, Jeremy C; Baudry, Jerome; Quarles, L Darryl. A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia. Science Signaling. 2016;9(455):ra113.