Clonality: Monoclonal
Host: Rat
Purification: Ig-PG
Reactivity: Mouse, Rat, Human
Gene Symbol: KL
Gene ID: 9365
Concentration: 0.25mg/mL
Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may beinactive as aglycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klothopeptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Documents & Links for Anti Klotho mAb (Clone KM2076) | |
Datasheet | kal-ko603_anti-klotho-mab-clone-km2076_datasheet.pdf |
Documents & Links for Anti Klotho mAb (Clone KM2076) | |
Datasheet | kal-ko603_anti-klotho-mab-clone-km2076_datasheet.pdf |
Citations for Anti Klotho mAb (Clone KM2076) – 3 Found |
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29;289(35):24700-15. doi: 10.1074/jbc.M114.567321. Epub 2014 Jul 18. PubMed |
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. J Biol Chem. 2013 Dec 20;288(51):36302-11. doi: 10.1074/jbc.M113.490052. Epub 2013 Nov 11. PubMed |
Development of an α-Klotho Recognizing High-Affinity Peptide Probe from In-Solution Enrichment. JACS Au. 2024 Apr 10;4(4):1334-1344. doi: 10.1021/jacsau.3c00650. eCollection 2024 Apr 22. PubMed |