Anti Klotho mAb (Clone KM2076)

Cosmo Bio LTD

Catalog No: KAL-KO603

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Gene Symbol: KL

Gene ID: 9365

Concentration: 0.25mg/mL

Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may beinactive as aglycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klothopeptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Citations for Anti Klotho mAb (Clone KM2076) – 3 Found

Zeldich, Ella; Chen, Ci-Di; Colvin, Teresa A; Bove-Fenderson, Erin A; Liang, Jennifer; Tucker Zhou, Tracey B; Harris, David A; Abraham, Carmela R. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. The Journal Of Biological Chemistry. 2014;289(35):24700-15. 

Tucker Zhou, Tracey B; King, Gwendalyn D; Chen, CiDi; Abraham, Carmela R. Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. The Journal Of Biological Chemistry. 2013;288(51):36302-11. 

Zhang, Peiyuan; Ye, Xiyun; Wang, John C K; Smith, Corey L; Sousa, Silvino; Loas, Andrei; Eaton, Dan L; Preciado López, Magdalena; Pentelute, Bradley L. Development of an α-Klotho Recognizing High-Affinity Peptide Probe from In-Solution Enrichment. Jacs Au. 2024;4(4):1334-1344.