Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Human recombinant IL-32 does not exhibit similarities with known cytokine families, yet several properties are typical of a pro-inflammatory cytokine. It was discovered accidentally while studying the genes induced by IL-18 and was found to stimulate the production of various chemokines, pro-inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α and macrophage inflammatory protein-2 (MIP-2). Inflammation or infection with various pathogens including Mycobacterium tuberculosis, Epstein-Barr virus (EBV), human immunodeficiency virus (HIV) and influenza A virus have been reported to induce the expression of IL-32. The IL-32 gene is located on human chromosome 16 p13.3, which is organized into eight exons with six splice variants of the gene; these variants have been described as IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ε and IL-32ζ, of which, IL-32α is the most abundant transcript. Anti-tumor activity of NK cells is provoked by IL-12 and IL-18, both of which induce IL-32 production that stimulates TNF-α synthesis enhancing NK apoptotic activity. IL-32 was found in cytosol as well as in the nucleus. Park et al. reported that IL-32 enhances the anti-tumor activity specifically for NK-92 cells upon introduction of the death receptor and the activation of caspase-3 pathway in cancer cells. IL-32 has been reported to play a key role in the pathogenesis of various disorders, including infectious autoimmune and inflammatory diseases. Anti-IL-32 polyclonal antibody obtained from rabbit immunization with purified E. coli-derived recombinant human IL-32. This antibody can be used for the detection of IL-32 by immunoblotting and flow cytometry.
References:
Goda, C et al., Int. Immunol. 18:233-240, 2006
| Product Specifications |
| Application |
FC, WB |
| Reactivity |
Human |
| Clonality |
Polyclonal |
| Host |
Rabbit |
