Interleukin 18 (IL-18) is an 18 kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12.
| Product Specifications | |
| Application | IP, Neutralization |
| Reactivity | Mouse |
| Clonality | Monoclonal IgG1 |
| Host | Rat |
| Immunogen | Recombinant mouse IL-18 |
| Gene ID - Human | |
| Gene ID - Mouse | |
| Formulation | 100 μg IgG in 100 μL volume of PBS containing 50% glycerol. No preservative is contained. |
| Citations for Anti-IL-18 (Clone 93-10C) (Mouse) mAb (Clone: 93-10C) – 10 Found |
| Fukao, T; Matsuda, S; Koyasu, S. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. Journal Of Immunology (Baltimore, Md. : 1950). 2000;164(1):64-71. PubMed - Comments: Used in: NT |
| Malmgaard, Lene; Paludan, Søren R. Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2. The Journal Of General Virology. 2003;84(Pt 9):2497-2500. PubMed - Comments: Used in: NT |
| Wang, Shan-Ze; Bao, Yi-Xiao; Rosenberger, Cynthia L; Tesfaigzi, Yohannes; Stark, James M; Harrod, Kevin S. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. Journal Of Immunology (Baltimore, Md. : 1950). 2004;173(6):4040-9. PubMed - Comments: Used in: NT |
| Beadling, Carol; Slifka, Mark K. Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood. 2005;105(3):1179-86. PubMed - Comments: Used in: NT |
| Chaix, Julie; Tessmer, Marlowe S; Hoebe, Kasper; Fuséri, Nicolas; Ryffel, Bernhard; Dalod, Marc; Alexopoulou, Lena; Beutler, Bruce; Brossay, Laurent; Vivier, Eric; Walzer, Thierry. Cutting edge: Priming of NK cells by IL-18. Journal Of Immunology (Baltimore, Md. : 1950). 2008;181(3):1627-31. PubMed - Comments: Used in: NT |
| Humann, Jessica; Lenz, Laurel L. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. Journal Of Immunology (Baltimore, Md. : 1950). 2010;184(9):5172-8. PubMed - Comments: Used in: NT |
| Matsunaga, Hisayuki; Hokari, Ryota; Ueda, Toshihide; Kurihara, Chie; Hozumi, Hideaki; Higashiyama, Masaaki; Okada, Yoshikiyo; Watanabe, Chikako; Komoto, Shunsuke; Nakamura, Mitsuyasu; Kawaguchi, Atsushi; Nagao, Shigeaki; Sekiyama, Atsuo; Miura, Soichiro. Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18. American Journal Of Physiology. Gastrointestinal And Liver Physiology. 2011;301(3):G555-64. PubMed - Comments: Used in: NT |
| Matsunaga, Hisayuki; Hokari, Ryota; Ueda, Toshihide; Kurihara, Chie; Hozumi, Hideaki; Higashiyama, Masaaki; Okada, Yoshikiyo; Watanabe, Chikako; Komoto, Shunsuke; Nakamura, Mitsuyasu; Kawaguchi, Atsushi; Nagao, Shigeaki; Sekiyama, Atsuo; Miura, Soichiro. Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18. American Journal Of Physiology. Gastrointestinal And Liver Physiology. 2011;301(3):G555-64. PubMed - Comments: Used in: DB |
| Kahlenberg, J Michelle; Carmona-Rivera, Carmelo; Smith, Carolyne K; Kaplan, Mariana J. Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. Journal Of Immunology (Baltimore, Md. : 1950). 2013;190(3):1217-26. PubMed - Comments: Used in: NT |
| Chen, Jin-Mei; Li, Qing-Wei; Jiang, Guo-Xin; Liu, Jian-Sheng; Cheng, Qi. IL-18 induced IL-23/IL-17 expression impairs Aβ clearance in cultured THP-1 and BV2 cells. Cytokine. 2019;119:113-118. PubMed - Comments: Used in: NT |