IGF2BP3/IMP3 is identical to the KH domain containing protein overexpressed in cancer (KOC). The protein encoded by this gene was found to bind in vivo to IGF2 leader 3 and leader 4 mRNAs and H19 RNA. Binding of IMP3 to the 5' UTR of the IGF2 leader 3 mRNA represses translation of IGF2 during late development.
Polyclonal Antibody of 200 µl targeting IGF2BP3/IMP3 for IP, RIP, WB.
| Product Specifications | |
| Application | IP, WB, RIP |
| Reactivity | Human, Mouse |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Peptide bond synthesis HQQQKALQSGPPQSRRK KLH (563-579 aa) |
| Formulation | 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Citations for Anti-IGF2BP3 (IMP3) (Human/Mouse) pAb – 16 Found |
| Ueki, Arisa; Shimizu, Takatsune; Masuda, Kenta; Yamaguchi, Sayaka I; Ishikawa, Tomoki; Sugihara, Eiji; Onishi, Nobuyuki; Kuninaka, Shinji; Miyoshi, Keita; Muto, Akihiro; Toyama, Yoshiaki; Banno, Kouji; Aoki, Daisuke; Saya, Hideyuki. Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells. Plos One. 7(11):e50621. PubMed - Comments: Used in: WB |
| Lederer, Marcell; Bley, Nadine; Schleifer, Christian; Hüttelmaier, Stefan. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. Seminars In Cancer Biology. 2014;29:3-12. PubMed - Comments: Used in: WB |
| Pasiliao, Clarissa C; Chang, Che-Wei A; Sutherland, Brent W; Valdez, Shannon M; Schaeffer, David; Yapp, Donald T; Ng, Sylvia S W. The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion. Bmc Cancer. 2015;15:266. PubMed - Comments: Used in: RIP |
| Palanichamy, Jayanth Kumar; Tran, Tiffany M; Howard, Jonathan M; Contreras, Jorge R; Fernando, Thilini R; Sterne-Weiler, Timothy; Katzman, Sol; Toloue, Masoud; Yan, Weihong; Basso, Giuseppe; Pigazzi, Martina; Sanford, Jeremy R; Rao, Dinesh S. RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation. The Journal Of Clinical Investigation. 2016;126(4):1495-511. PubMed |
| Sundararaman, Balaji; Zhan, Lijun; Blue, Steven M; Stanton, Rebecca; Elkins, Keri; Olson, Sara; Wei, Xintao; Van Nostrand, Eric L; Pratt, Gabriel A; Huelga, Stephanie C; Smalec, Brendan M; Wang, Xiaofeng; Hong, Eurie L; Davidson, Jean M; Lécuyer, Eric; Graveley, Brenton R; Yeo, Gene W. Resources for the Comprehensive Discovery of Functional RNA Elements. Molecular Cell. 2016;61(6):903-13. PubMed - Comments: Used in: ICC |
| Conway, Anne E; Van Nostrand, Eric L; Pratt, Gabriel A; Aigner, Stefan; Wilbert, Melissa L; Sundararaman, Balaji; Freese, Peter; Lambert, Nicole J; Sathe, Shashank; Liang, Tiffany Y; Essex, Anthony; Landais, Severine; Burge, Christopher B; Jones, D Leanne; Yeo, Gene W. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Reports. 2016;15(3):666-679. PubMed - Comments: Used in: WB |
| Conway, Anne E; Van Nostrand, Eric L; Pratt, Gabriel A; Aigner, Stefan; Wilbert, Melissa L; Sundararaman, Balaji; Freese, Peter; Lambert, Nicole J; Sathe, Shashank; Liang, Tiffany Y; Essex, Anthony; Landais, Severine; Burge, Christopher B; Jones, D Leanne; Yeo, Gene W. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Reports. 2016;15(3):666-679. PubMed - Comments: Used in: IP |
| Conway, Anne E; Van Nostrand, Eric L; Pratt, Gabriel A; Aigner, Stefan; Wilbert, Melissa L; Sundararaman, Balaji; Freese, Peter; Lambert, Nicole J; Sathe, Shashank; Liang, Tiffany Y; Essex, Anthony; Landais, Severine; Burge, Christopher B; Jones, D Leanne; Yeo, Gene W. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Reports. 2016;15(3):666-679. PubMed - Comments: Used in: ICC |
| Conway, Anne E; Van Nostrand, Eric L; Pratt, Gabriel A; Aigner, Stefan; Wilbert, Melissa L; Sundararaman, Balaji; Freese, Peter; Lambert, Nicole J; Sathe, Shashank; Liang, Tiffany Y; Essex, Anthony; Landais, Severine; Burge, Christopher B; Jones, D Leanne; Yeo, Gene W. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Reports. 2016;15(3):666-679. PubMed |
| PubMed |
| Degrauwe, Nils; Schlumpf, Tommy B; Janiszewska, Michalina; Martin, Patricia; Cauderay, Alexandra; Provero, Paolo; Riggi, Nicolo; Suvà, Mario-L; Paro, Renato; Stamenkovic, Ivan. The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. Cell Reports. 2016;15(8):1634-47. PubMed - Comments: Used in: WB |
| Ennajdaoui, Hanane; Howard, Jonathan M; Sterne-Weiler, Timothy; Jahanbani, Fereshteh; Coyne, Doyle J; Uren, Philip J; Dargyte, Marija; Katzman, Sol; Draper, Jolene M; Wallace, Andrew; Cazarez, Oscar; Burns, Suzanne C; Qiao, Mei; Hinck, Lindsay; Smith, Andrew D; Toloue, Masoud M; Blencowe, Benjamin J; Penalva, Luiz O F; Sanford, Jeremy R. IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC. Cell Reports. 2016;15(9):1876-83. PubMed - Comments: Used in: RIP |
| JnBaptiste, Courtney K; Gurtan, Allan M; Thai, Kevin K; Lu, Victoria; Bhutkar, Arjun; Su, Mei-Ju; Rotem, Asaf; Jacks, Tyler; Sharp, Phillip A. Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. Genes & Development. 2017;31(7):674-687. PubMed - Comments: Used in: WB |
| Kim, Hye-Youn; Ha Thi, Huyen Trang; Hong, Suntaek. IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor. Cancer Letters. 2018;415:30-39. PubMed - Comments: Used in: RIP |
| Markmiller, Sebastian; Soltanieh, Sahar; Server, Kari L; Mak, Raymond; Jin, Wenhao; Fang, Mark Y; Luo, En-Ching; Krach, Florian; Yang, Dejun; Sen, Anindya; Fulzele, Amit; Wozniak, Jacob M; Gonzalez, David J; Kankel, Mark W; Gao, Fen-Biao; Bennett, Eric J; Lécuyer, Eric; Yeo, Gene W. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018;172(3):590-604.e13. PubMed - Comments: Used in: WB |
| Markmiller, Sebastian; Soltanieh, Sahar; Server, Kari L; Mak, Raymond; Jin, Wenhao; Fang, Mark Y; Luo, En-Ching; Krach, Florian; Yang, Dejun; Sen, Anindya; Fulzele, Amit; Wozniak, Jacob M; Gonzalez, David J; Kankel, Mark W; Gao, Fen-Biao; Bennett, Eric J; Lécuyer, Eric; Yeo, Gene W. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018;172(3):590-604.e13. PubMed - Comments: Used in: IP |
| Markmiller, Sebastian; Soltanieh, Sahar; Server, Kari L; Mak, Raymond; Jin, Wenhao; Fang, Mark Y; Luo, En-Ching; Krach, Florian; Yang, Dejun; Sen, Anindya; Fulzele, Amit; Wozniak, Jacob M; Gonzalez, David J; Kankel, Mark W; Gao, Fen-Biao; Bennett, Eric J; Lécuyer, Eric; Yeo, Gene W. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018;172(3):590-604.e13. PubMed - Comments: Used in: ICC |