Application: WB, IHC, IF, IP, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
| Documents & Links for Anti HNRNPK mAb (Clone 3G7) | |
| Datasheet | Anti HNRNPK mAb (Clone 3G7) Datasheet |
| Vendor Page | Anti HNRNPK mAb (Clone 3G7) at CUSABIO |
| Documents & Links for Anti HNRNPK mAb (Clone 3G7) | |
| Datasheet | Anti HNRNPK mAb (Clone 3G7) Datasheet |
| Vendor Page | Anti HNRNPK mAb (Clone 3G7) |
