Application: IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: 3-hydroxy-3-methylglutaryl-CoA reductase
Gene Name: HMGCR
Alternative Gene Name:
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000021670: 99%, ENSRNOG00000016122: 99%
Entrez Gene ID: 3156
Uniprot ID: P04035
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: 3-hydroxy-3-methylglutaryl-CoA reductase
Gene Name: HMGCR
Alternative Gene Name:
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000021670: 99%, ENSRNOG00000016122: 99%
Entrez Gene ID: 3156
Uniprot ID: P04035
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti HMGCR pAb (ATL-HPA008338) | |
| Antigen | PrEST Antigen HMGCR (ATL-APrEST86736) |
| Documents & Links for Anti HMGCR pAb (ATL-HPA008338) | |
| Datasheet | Anti HMGCR pAb (ATL-HPA008338) Datasheet (External Link) |
| Vendor Page | Anti HMGCR pAb (ATL-HPA008338) at Atlas |
| Documents & Links for Anti HMGCR pAb (ATL-HPA008338) | |
| Datasheet | Anti HMGCR pAb (ATL-HPA008338) Datasheet (External Link) |
| Vendor Page | Anti HMGCR pAb (ATL-HPA008338) |
| Citations for Anti HMGCR pAb (ATL-HPA008338) – 10 Found |
| High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer. Oncotarget. 2016 Sep 13;7(37):59640-59651. doi: 10.18632/oncotarget.10746. PubMed |
| Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study. Br J Cancer. 2017 Jun 6;116(12):1652-1659. doi: 10.1038/bjc.2017.139. Epub 2017 May 18. PubMed |
| Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. J Exp Med. 2018 Jan 2;215(1):177-195. doi: 10.1084/jem.20170399. Epub 2017 Dec 13. PubMed |
| Interactions Between ABCB1 Genotype and Preoperative Statin Use Impact Clinical Outcomes Among Breast Cancer Patients. Front Oncol. 2018 Oct 12;8:428. doi: 10.3389/fonc.2018.00428. eCollection 2018. PubMed |
| Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. Breast Cancer Res Treat. 2013 Apr;138(2):499-508. doi: 10.1007/s10549-013-2473-6. Epub 2013 Mar 8. PubMed |
| HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome. Diagn Pathol. 2014 Apr 7;9:78. doi: 10.1186/1746-1596-9-78. PubMed |
| Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients. BMC Clin Pathol. 2015 May 20;15:8. doi: 10.1186/s12907-015-0008-2. eCollection 2015. PubMed |
| HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes. Sci Rep. 2016 Oct 7;6:35121. doi: 10.1038/srep35121. PubMed |
| SREBP2 is upregulated in esophageal squamous cell carcinoma and co‑operates with c‑Myc to regulate HMGCR expression. Mol Med Rep. 2019 Oct;20(4):3003-3010. doi: 10.3892/mmr.2019.10577. Epub 2019 Aug 9. PubMed |
| Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence. J Cell Mol Med. 2020 Jan;24(1):276-284. doi: 10.1111/jcmm.14717. Epub 2019 Nov 20. PubMed |