Anti HMGCL pAb (ATL-HPA004727 w/enhanced validation)

Atlas

Catalog No: ATL-HPA004727-25

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Application: WB, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Gene Name: HMGCL
Alternative Gene Name: HL
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000028672: 84%, ENSRNOG00000009422: 86%
Entrez Gene ID: 3155
Uniprot ID: P35914
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti HMGCL pAb (ATL-HPA004727 w/enhanced validation) – 4 Found

Inactivation of HMGCL promotes proliferation and metastasis of nasopharyngeal carcinoma by suppressing oxidative stress.
Sci Rep. 2017 Sep 20;7(1):11954. doi: 10.1038/s41598-017-11025-2. 

Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
Cell Cycle. 2012 Nov 1;11(21):3956-63. doi: 10.4161/cc.22136. Epub 2012 Sep 19. 

Dysregulation of Ketone Body Metabolism Is Associated With Poor Prognosis for Clear Cell Renal Cell Carcinoma Patients.
Front Oncol. 2019 Dec 17;9:1422. doi: 10.3389/fonc.2019.01422. eCollection 2019. 

Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel.
Oncogene. 2021 Nov;40(44):6284-6298. doi: 10.1038/s41388-021-02008-9. Epub 2021 Sep 28.