Clonality: Monoclonal
Host: Mouse
Reactivity: Human
Quantity: 100 µL/vial (1 mg/mL)
Clone: EMR8-5 Isotype: IgG1
Buffer: Phosphate buffered saline pH7.4, 0.05% Sodium Azide
Immunogen: recombinant HLA-A*2402 extracellular domain
Specificity: Heavy chains of HLA-A, HLA-B, HLA-C
Applications: Immunohistochemistry (formalin-fixed tissue, 1:50 ~ 1:100) Western blotting
Storage: Store at 2 ~ 8°C. For long-term storage aliquot and store at -20°C. Avoid freeze / thaw cycles.
References:
1. Torigoe T, Asanuma H, Shimozawa K, et al. Immunohistochemical analysis of HLA class I expression in tumor tissues revealed unusually high frequency of down-regulation in breast cancer tissues. J. Translational Med. Submitted
2. Komori H, Nakatsura T, Senju S, Yoshitake Y, Motomura Y, Beppu T, Matsui M, Torigoe T, Sato N, Baba H, Nishimura Y. Identification of HLA-A2 or -A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy for hepatocellular carcinoma. Clinical Cancer Res. 12, 2689-2699 (2006)
3. Kitamura H, Torigoe T, Sato N, et. al, Expression and antigenecity of surviving, and inhibitor of apotosis family member, in bladder cancer: implications for specific immunotherapy. J Urology Submitted. 67, 955-959 (2006)
Documents & Links for Anti HLA Class I-A, B, C mAb (Clone EMR8-5) | |
Datasheet | Anti HLA Class I-A, B, C mAb (Clone EMR8-5) Datasheet |
Documents & Links for Anti HLA Class I-A, B, C mAb (Clone EMR8-5) | |
Datasheet | Anti HLA Class I-A, B, C mAb (Clone EMR8-5) Datasheet |
Citations for Anti HLA Class I-A, B, C mAb (Clone EMR8-5) – 1 Found |
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. J Immunol. 2013 Dec 15;191(12):6261-72. doi: 10.4049/jimmunol.1301597. Epub 2013 Nov 15. PubMed |