Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| Product Specifications |
| Application |
IHC, FC, ELISA |
| Reactivity |
Human |
| Clonality |
Monoclonal (Clone No.: 2100000000) |
