Anti GRHL2 pAb (ATL-HPA004820)

Atlas

Catalog No: ATL-HPA004820-25

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Application: IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: grainyhead-like 2 (Drosophila)
Gene Name: GRHL2
Alternative Gene Name: BOM, DFNA28, FLJ13782, TFCP2L3
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000022286: 87%, ENSRNOG00000007000: 87%
Entrez Gene ID: 79977
Uniprot ID: Q6ISB3
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti GRHL2 pAb (ATL-HPA004820) – 34 Found

GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells.
J Cell Biol. 2015 Nov 9;211(3):669-82. doi: 10.1083/jcb.201506014. Epub 2015 Nov 2. 

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.
Sci Rep. 2016 Feb 18;6:19943. doi: 10.1038/srep19943. 

Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer.
Cancer Res. 2017 Jul 1;77(13):3417-3430. doi: 10.1158/0008-5472.CAN-16-1616. Epub 2017 May 4. 

GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency.
Cell Stem Cell. 2018 Aug 2;23(2):226-238.e4. doi: 10.1016/j.stem.2018.06.005. Epub 2018 Jul 12. 

The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2.
Mol Cell Biol. 2019 Jan 16;39(3):e00417-18. doi: 10.1128/MCB.00417-18. Print 2019 Feb 1. 

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer.
Genome Biol. 2019 May 13;20(1):91. doi: 10.1186/s13059-019-1698-z. 

Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.
Nat Commun. 2019 Jun 6;10(1):2487. doi: 10.1038/s41467-019-10164-6. 

Evaluation of 6-mercaptopurine in a cell culture model of adaptable triple-negative breast cancer with metastatic potential.
Oncotarget. 2019 Jun 4;10(38):3681-3693. doi: 10.18632/oncotarget.26978. eCollection 2019 Jun 4. 

The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells.
Commun Biol. 2019 Jul 24;2:272. doi: 10.1038/s42003-019-0506-3. eCollection 2019. 

A modular master regulator landscape controls cancer transcriptional identity.
Cell. 2021 Jan 21;184(2):334-351.e20. doi: 10.1016/j.cell.2020.11.045. Epub 2021 Jan 11. 

Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.
J Histochem Cytochem. 2021 Jun;69(6):373-388. doi: 10.1369/00221554211013715. Epub 2021 May 14. 

3D genome organization in the epithelial-mesenchymal transition spectrum.
Genome Biol. 2022 May 30;23(1):121. doi: 10.1186/s13059-022-02687-x. 

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.
J Biol Chem. 2012 Oct 26;287(44):37282-95. doi: 10.1074/jbc.M112.408401. Epub 2012 Sep 6. 

Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9356-61. doi: 10.1073/pnas.1307589110. Epub 2013 May 20. 

Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Cancer Res. 2013 Oct 15;73(20):6299-309. doi: 10.1158/0008-5472.CAN-12-4082. Epub 2013 Aug 13. 

Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.
Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L405-19. doi: 10.1152/ajplung.00143.2013. Epub 2013 Dec 27. 

Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1.
Cancer Biol Ther. 2014 Jul;15(7):878-87. doi: 10.4161/cbt.28877. Epub 2014 Apr 22. 

Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer.
Int J Clin Exp Pathol. 2014 Oct 15;7(11):7409-18. eCollection 2014. 

Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer.
J Cancer. 2015 Feb 15;6(4):342-50. doi: 10.7150/jca.10969. eCollection 2015. 

Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.
Sci Rep. 2016 Feb 26;6:22250. doi: 10.1038/srep22250. 

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.
Cell Rep. 2016 Dec 6;17(10):2715-2723. doi: 10.1016/j.celrep.2016.11.028. 

Grainyhead-like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression.
Cancer Med. 2017 Nov;6(11):2686-2696. doi: 10.1002/cam4.1212. Epub 2017 Sep 29. 

Ectopic GRHL2 Expression Due to Non-coding Mutations Promotes Cell State Transition and Causes Posterior Polymorphous Corneal Dystrophy 4.
Am J Hum Genet. 2018 Mar 1;102(3):447-459. doi: 10.1016/j.ajhg.2018.02.002. 

Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers.
Mol Immunol. 2019 Jan;105:137-149. doi: 10.1016/j.molimm.2018.11.006. Epub 2018 Nov 30. 

Estrogen receptor signaling is reprogrammed during breast tumorigenesis.
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11437-11443. doi: 10.1073/pnas.1819155116. Epub 2019 May 20. 

The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
Cell Rep. 2019 Oct 22;29(4):889-903.e10. doi: 10.1016/j.celrep.2019.09.032. 

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.
Dis Model Mech. 2020 Mar 25;13(3):dmm042218. doi: 10.1242/dmm.042218. 

Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer.
Sci Adv. 2020 Jun 5;6(23):eaaz7249. doi: 10.1126/sciadv.aaz7249. eCollection 2020 Jun. 

Cis-regulatory chromatin loops analysis identifies GRHL3 as a master regulator of surface epithelium commitment.
Sci Adv. 2022 Jul 15;8(28):eabo5668. doi: 10.1126/sciadv.abo5668. Epub 2022 Jul 13. 

GRHL2-controlled gene expression networks in luminal breast cancer.
Cell Commun Signal. 2023 Jan 23;21(1):15. doi: 10.1186/s12964-022-01029-5. 

GRHL2 Regulation of Growth/Motility Balance in Luminal versus Basal Breast Cancer.
Int J Mol Sci. 2023 Jan 28;24(3):2512. doi: 10.3390/ijms24032512. 

GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development.
iScience. 2023 Feb 3;26(3):106125. doi: 10.1016/j.isci.2023.106125. eCollection 2023 Mar 17. 

Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma.
Nat Commun. 2022 Jan 10;13(1):31. doi: 10.1038/s41467-021-27660-3. 

GRHL2 Enhances Phosphorylated Estrogen Receptor (ER) Chromatin Binding and Regulates ER-Mediated Transcriptional Activation and Repression.
Mol Cell Biol. 2022 Oct 20;42(10):e0019122. doi: 10.1128/mcb.00191-22. Epub 2022 Aug 29.