Anti FUS pAb (ATL-HPA008784 w/enhanced validation)

Atlas

Catalog No: ATL-HPA008784-25

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Application: WB, ICC, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human, Mouse, Rat 
Protein Description: FUS RNA binding protein
Gene Name: FUS
Alternative Gene Name: ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000030795: 91%, ENSRNOG00000023360: 91%
Entrez Gene ID: 2521
Uniprot ID: P35637
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti FUS pAb (ATL-HPA008784 w/enhanced validation) – 38 Found

Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy.
J Neuropathol Exp Neurol. 2015 Apr;74(4):370-9. doi: 10.1097/NEN.0000000000000180. 

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7821-6. doi: 10.1073/pnas.1509744112. Epub 2015 Jun 8. 

Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.
Acta Neuropathol Commun. 2016 Apr 4;4:36. doi: 10.1186/s40478-016-0304-9. 

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.
EMBO J. 2017 Jun 14;36(12):1669-1687. doi: 10.15252/embj.201695957. Epub 2017 Apr 4. 

Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Front Cell Neurosci. 2019 Jun 12;13:256. doi: 10.3389/fncel.2019.00256. eCollection 2019. 

Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
Nat Neurosci. 2021 Aug;24(8):1077-1088. doi: 10.1038/s41593-021-00859-9. Epub 2021 May 31. 

A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Acta Neuropathol Commun. 2022 Feb 12;10(1):20. doi: 10.1186/s40478-022-01314-x. 

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Acta Neuropathol. 2009 Nov;118(5):605-16. doi: 10.1007/s00401-009-0581-5. Epub 2009 Aug 9. 

A new subtype of frontotemporal lobar degeneration with FUS pathology.
Brain. 2009 Nov;132(Pt 11):2922-31. doi: 10.1093/brain/awp214. Epub 2009 Aug 11. 

FUS pathology in basophilic inclusion body disease.
Acta Neuropathol. 2009 Nov;118(5):617-27. doi: 10.1007/s00401-009-0598-9. Epub 2009 Oct 15. 

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration.
J Neurol. 2010 May;257(5):747-53. doi: 10.1007/s00415-009-5404-z. Epub 2009 Nov 28. 

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.
Acta Neuropathol. 2010 Jul;120(1):33-41. doi: 10.1007/s00401-010-0698-6. Epub 2010 May 20. 

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Ann Neurol. 2010 Jun;67(6):739-48. doi: 10.1002/ana.22051. 

Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.
Nucleic Acids Res. 2011 Apr;39(7):2781-98. doi: 10.1093/nar/gkq1162. Epub 2010 Nov 24. 

Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry.
Cerebellum. 2011 Dec;10(4):720-31. doi: 10.1007/s12311-011-0281-2. 

A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies.
Brain. 2011 Sep;134(Pt 9):2548-64. doi: 10.1093/brain/awr160. Epub 2011 Jul 12. 

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
Brain. 2011 Sep;134(Pt 9):2595-609. doi: 10.1093/brain/awr201. Epub 2011 Aug 19. 

Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations.
Brain. 2012 Mar;135(Pt 3):693-708. doi: 10.1093/brain/awr355. Epub 2012 Feb 2. 

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
EMBO J. 2012 Nov 14;31(22):4258-75. doi: 10.1038/emboj.2012.261. Epub 2012 Sep 11. 

Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Acta Neuropathol. 2013 Apr;125(4):523-33. doi: 10.1007/s00401-013-1078-9. Epub 2013 Jan 22. 

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
J Clin Invest. 2014 Mar;124(3):981-99. doi: 10.1172/JCI72723. Epub 2014 Feb 10. 

Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.
Am J Neurodegener Dis. 2014 Sep 6;3(2):93-102. eCollection 2014. 

Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4769-78. doi: 10.1073/pnas.1406162111. Epub 2014 Oct 16. 

Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Acta Neuropathol Commun. 2014 Dec 10;2:172. doi: 10.1186/s40478-014-0172-0. 

A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration.
Acta Neuropathol. 2015 Jul;130(1):145-57. doi: 10.1007/s00401-015-1431-2. Epub 2015 Apr 28. 

Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Acta Neuropathol Commun. 2015 Jul 10;3:43. doi: 10.1186/s40478-015-0216-0. 

Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Front Cell Neurosci. 2016 Jan 12;9:496. doi: 10.3389/fncel.2015.00496. eCollection 2015. 

Frontotemporal Dementia: Correlations Between Psychiatric Symptoms and Pathology.
Ann Neurol. 2020 Jun;87(6):950-961. doi: 10.1002/ana.25739. Epub 2020 Apr 25. 

Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases.
Brain Pathol. 2020 Jul;30(4):811-830. doi: 10.1111/bpa.12843. Epub 2020 May 6. 

Quantitative patterns of motor cortex proteinopathy across ALS genotypes.
Acta Neuropathol Commun. 2020 Jul 2;8(1):98. doi: 10.1186/s40478-020-00961-2. 

A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP.
Brain Pathol. 2021 Mar;31(2):267-282. doi: 10.1111/bpa.12924. Epub 2021 Feb 11. 

Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients.
Transl Neurodegener. 2021 May 31;10(1):17. doi: 10.1186/s40035-021-00241-6. 

Neuronal intermediate filament inclusion disease may be incorrectly classified as a subtype of FTLD-FUS.
Free Neuropathol. 2020;1:1-9. doi: 10.17879/freeneuropathology-2020-2639. Epub 2020 Mar 11. 

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Nat Commun. 2022 Jun 13;13(1):3380. doi: 10.1038/s41467-022-31098-6. 

Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index.
Genome Biol. 2021 Aug 17;22(1):229. doi: 10.1186/s13059-021-02456-2. 

Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions.
Sci Rep. 2022 Mar 14;12(1):4347. doi: 10.1038/s41598-022-08044-z. 

Acid sphingomyelinase inhibition improves motor behavioral deficits and neuronal loss in an amyotrophic lateral sclerosis mouse model.
BMB Rep. 2022 Dec;55(12):621-626. doi: 10.5483/BMBRep.2022.55.12.142. 

Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights.
Brain. 2023 Jan 5;146(1):307-320. doi: 10.1093/brain/awac043.