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Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Background
RNA polymerase II (RNAPII) transcribes all protein-coding genes and many non-coding genes, and the activity of RNAPII correlates with the phosphorylation state of RPB1, the large catalytic subunit of RNAPII.. RPB1 has an unusual C-terminal domain (CTD) that consists of repeats of the heptapeptide consensus sequence N-Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7-C, of which there are 52 copies in mammals. The amino acids in these repeats are potential targets for modification, such as phosphorylation and glycosylation.
| Antigen/Source | RNA polymerase 2, CTD Ser5ph |
| Host | Rat |
| Immunogen | Human |
| Reacts with | Human/Mouse/Rat/Monkey/Hamster |
| Clone | 1H4B6 |
| Isotype | IgG2b |
| Conjugation | Unlabeled |
| Fraction | Ig fraction - Ion Exchange /Gel Filtration |
| Applications | Western Blot/Immunocytochemistry (cell)/Chromatin Immunoprecipitation |
| Preservative | 0.05% NaN3 in LIQ |
| Storage | -70C |
References
1) Odawara et al. (2011) BMC Genomics. 12:516. PMID: 22011111.
| Product Specifications | |
| Application | ChIP, ICC, WB, ELISA |
| Reactivity | Monkey, Mouse, Rat, Human, Hamster |
| Clonality | Monoclonal (Clone No.: 1H4B6) |
| Host | Rat |
| Documents & Links for Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser5 mAb (Clone 1H4B6) | |
| Datasheet | Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser5 mAb (Clone 1H4B6) Datasheet |
| Documents & Links for Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser5 mAb (Clone 1H4B6) | |
| Datasheet | Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser5 mAb (Clone 1H4B6) Datasheet |