Anti DAXX pAb (ATL-HPA008736 w/enhanced validation)

Atlas

Catalog No: ATL-HPA008736-25

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Application: WB, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: death-domain associated protein
Gene Name: DAXX
Alternative Gene Name: DAP6
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000002307: 47%, ENSRNOG00000000477: 50%
Entrez Gene ID: 1616
Uniprot ID: Q9UER7
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti DAXX pAb (ATL-HPA008736 w/enhanced validation) – 32 Found

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.
PLoS Genet. 2016 Feb 18;12(2):e1005850. doi: 10.1371/journal.pgen.1005850. eCollection 2016 Feb. 

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors.
Clin Cancer Res. 2017 Jan 15;23(2):600-609. doi: 10.1158/1078-0432.CCR-16-1113. Epub 2016 Jul 12. 

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes.
Sci Rep. 2016 Jul 14;6:29714. doi: 10.1038/srep29714. 

Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma.
J Pathol Clin Res. 2015 Mar 16;1(2):95-105. doi: 10.1002/cjp2.11. eCollection 2015 Apr. 

DAXX/ATRX and MEN1 genes are strong prognostic markers in pancreatic neuroendocrine tumors.
Oncotarget. 2017 Jul 25;8(30):49796-49806. doi: 10.18632/oncotarget.17964. 

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease.
Brain Pathol. 2019 Jan;29(1):45-52. doi: 10.1111/bpa.12618. Epub 2018 May 23. 

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner.
PLoS One. 2018 Sep 18;13(9):e0204159. doi: 10.1371/journal.pone.0204159. eCollection 2018. 

Importance of Promyelocytic Leukema Protein (PML) for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.
Front Microbiol. 2018 Oct 8;9:2324. doi: 10.3389/fmicb.2018.02324. eCollection 2018. 

Grading of Neuroendocrine Carcinomas: Correlation of (68)Ga-PET/CT Scan with Tissue Biomarkers.
Dis Markers. 2018 Dec 2;2018:6878409. doi: 10.1155/2018/6878409. eCollection 2018. 

A Comparison of Death Domain-Associated Protein 6 in Different Endometrial Carcinomas Histotypes.
Biomark Insights. 2019 Jul 23;14:1177271919864892. doi: 10.1177/1177271919864892. eCollection 2019. 

Telomere alterations in neurofibromatosis type 1-associated solid tumors.
Acta Neuropathol Commun. 2019 Aug 28;7(1):139. doi: 10.1186/s40478-019-0792-5. 

DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
Mol Cell. 2021 Jun 17;81(12):2533-2548.e9. doi: 10.1016/j.molcel.2021.03.041. Epub 2021 Apr 14. 

Immunohistochemical analyses of the expression profiles of INSM1, ATRX, DAXX and DLL3 in solid papillary carcinomas of the breast.
Oncol Lett. 2022 Apr;23(4):137. doi: 10.3892/ol.2022.13257. Epub 2022 Mar 1. 

Altered telomeres in tumors with ATRX and DAXX mutations.
Science. 2011 Jul 22;333(6041):425. doi: 10.1126/science.1207313. Epub 2011 Jun 30. 

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Nature. 2012 Jan 29;482(7384):226-31. doi: 10.1038/nature10833. 

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.
Mod Pathol. 2012 Jul;25(7):1033-9. doi: 10.1038/modpathol.2012.53. Epub 2012 May 11. 

Sp100 provides intrinsic immunity against human papillomavirus infection.
mBio. 2013 Nov 5;4(6):e00845-13. doi: 10.1128/mBio.00845-13. 

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas.
Nat Commun. 2015 Jan 21;6:6140. doi: 10.1038/ncomms7140. 

Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours.
Endocr Relat Cancer. 2015 Jun;22(3):L13-8. doi: 10.1530/ERC-15-0108. Epub 2015 Apr 21. 

ATRX represses alternative lengthening of telomeres.
Oncotarget. 2015 Jun 30;6(18):16543-58. doi: 10.18632/oncotarget.3846. 

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival.
Clin Cancer Res. 2017 Mar 15;23(6):1598-1606. doi: 10.1158/1078-0432.CCR-16-1147. Epub 2016 Sep 23. 

Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis.
Nat Commun. 2016 Dec 22;7:13867. doi: 10.1038/ncomms13867. 

Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors.
Cancer Cytopathol. 2017 Jul;125(7):544-551. doi: 10.1002/cncy.21857. Epub 2017 Apr 3. 

Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?
Oncotarget. 2017 Jun 20;8(25):41044-41063. doi: 10.18632/oncotarget.17008. 

Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia.
Brain Pathol. 2019 Jan;29(1):126-140. doi: 10.1111/bpa.12646. Epub 2018 Oct 17. 

Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells.
Mol Cancer Res. 2019 Dec;17(12):2480-2491. doi: 10.1158/1541-7786.MCR-19-0654. Epub 2019 Oct 14. 

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas.
Endocr Pathol. 2020 Jun;31(2):108-118. doi: 10.1007/s12022-020-09611-8. 

Death domain-associated protein (DAXX) expression is associated with poor survival in metastatic high-grade serous carcinoma.
Virchows Arch. 2020 Dec;477(6):857-864. doi: 10.1007/s00428-020-02842-4. Epub 2020 Jun 12. 

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size.
Gut. 2022 May;71(5):961-973. doi: 10.1136/gutjnl-2020-322595. Epub 2021 Apr 13. 

Enhancer of Zeste Homolog 2 (EZH2) Is a Marker of High-Grade Neuroendocrine Neoplasia in Gastroenteropancreatic and Pulmonary Tract and Predicts Poor Prognosis.
Cancers (Basel). 2022 Jun 8;14(12):2828. doi: 10.3390/cancers14122828. 

Telomere length alterations and ATRX/DAXX loss in pituitary adenomas.
Mod Pathol. 2020 Aug;33(8):1475-1481. doi: 10.1038/s41379-020-0523-2. Epub 2020 Mar 18. 

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.
EMBO Mol Med. 2022 Oct 10;14(10):e15859. doi: 10.15252/emmm.202215859. Epub 2022 Aug 3.