The cellular inhibitor of apoptosis 1 and 2 (c-IAP1 and c-IAP2) proteins were identified based on their homology to a family of viral and cellular IAP proteins known to bind to caspases and inhibit their activity .
This polyclonal antibody detects endogenous both c-IAP1 and c-IAP2 by western blotting.
| Product Specifications | |
| Application | WB |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant Ratfull length c-IAP1 |
| Formulation | Supplied in 20mM phosphatase buffer (pH 7.5), 300mM NaCl, 50% glycerol. |
| Storage | |
| Documents & Links for Anti-cIAP 1and 2 | |
| Datasheet | Anti-cIAP 1and 2 Datasheet |
| Documents & Links for Anti-cIAP 1and 2 | |
| Datasheet | Anti-cIAP 1and 2 Datasheet |
| Citations for Anti-cIAP 1and 2 – 9 Found |
| Marivin, A; Berthelet, J; Cartier, J; Paul, C; Gemble, S; Morizot, A; Boireau, W; Saleh, M; Bertoglio, J; Solary, E; Dubrez, L. cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene. 2014;33(48):5534-45. PubMed |
| Shutinoski, B; Alturki, N A; Rijal, D; Bertin, J; Gough, P J; Schlossmacher, M G; Sad, S. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death And Differentiation. 2016;23(10):1628-37. PubMed - Comments: Used in: WB |
| Dobson, Christine C; Naing, Thet; Beug, Shawn T; Faye, Mame D; Chabot, Janelle; St-Jean, Martin; Walker, Danielle E; LaCasse, Eric C; Stojdl, David F; Korneluk, Robert G; Holcik, Martin. Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model. Oncotarget. 2017;8(2):3495-3508. PubMed - Comments: Used in: WB |
| Patel, Rajen; Kim, Kwangsin; Shutinoski, Bojan; Wachholz, Kristina; Krishnan, Lakshmi; Sad, Subash. Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells. Cell Death And Differentiation. 2017;24(11):1900-1911. PubMed - Comments: Used in: WB |
| Kim, Dae-Sun; Dastidar, Himika; Zhang, Chunfen; Zemp, Franz J; Lau, Keith; Ernst, Matthias; Rakic, Andrea; Sikdar, Saif; Rajwani, Jahanara; Naumenko, Victor; Balce, Dale R; Ewanchuk, Ben W; Tailor, Pankaj; Yates, Robin M; Jenne, Craig; Gafuik, Chris; Mahoney, Douglas J. Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. Nature Communications. 2017;8(1):344. PubMed - Comments: Used in: WB |
| Alturki, Norah A; McComb, Scott; Ariana, Ardeshir; Rijal, Dikchha; Korneluk, Robert G; Sun, Shao-Cong; Alnemri, Emad; Sad, Subash. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. Cell Death & Disease. 2018;9(6):592. PubMed - Comments: Used in: WB |
| Beug, Shawn T; Cheung, Herman H; Sanda, Tarun; St-Jean, Martine; Beauregard, Caroline E; Mamady, Hapsatou; Baird, Stephen D; LaCasse, Eric C; Korneluk, Robert G. The transcription factor SP3 drives TNF-α expression in response to Smac mimetics. Science Signaling. 2019;12(566) PubMed - Comments: Used in: WB |
| Lala-Tabbert, Neena; Lejmi-Mrad, Rim; Timusk, Kristen; Fukano, Marina; Holbrook, Janelle; St-Jean, Martine; LaCasse, Eric C; Korneluk, Robert G. Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy. Skeletal Muscle. 2019;9(1):13. PubMed - Comments: Used in: WB |
| Shekhar, Tanmay M; Burvenich, Ingrid J G; Harris, Michael A; Rigopoulos, Angela; Zanker, Damien; Spurling, Alex; Parker, Belinda S; Walkley, Carl R; Scott, Andrew M; Hawkins, Christine J. Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice. Bmc Cancer. 2019;19(1):924. PubMed - Comments: Used in: WB |