Anti CDK4 mAb (Clone 8F2)

Catalog No:
CSB-RA965615A0HU-50
$221.00
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Product Specifications
Application WB, IP, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 8F2)
Documents & Links for Anti CDK4 mAb (Clone 8F2)
Datasheet Anti CDK4 mAb (Clone 8F2) Datasheet
Vendor Page Anti CDK4 mAb (Clone 8F2) at CUSABIO

Documents & Links for Anti CDK4 mAb (Clone 8F2)
Datasheet Anti CDK4 mAb (Clone 8F2) Datasheet
Vendor Page Anti CDK4 mAb (Clone 8F2)