Anti Fish T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) mAb (Clone 2C3)

Cosmo Bio LTD

Catalog No: CAC-NIH-NA-02

• 

Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

The two major subsets of T lymphocytes, helper and cytotoxic T cells, are defined by expression of CD4 and CD8 glycoproteins, respectively. T cell coreceptor CD8 exists on mature T cells as homodimers of CD8α polypeptide chains and heterodimers of CD8α and CD8β chains. T cells expressing the CD8 surface antigens constitute an important component of the specific effector mechanism in immuno-surveillance against virus-infected or transformed cells and are thus termed cytotoxic T-lymphocytes (CTLs). CD8+ CTL recognize endogenously derived peptides in the context of the MHC class I molecule. This recognition process also involves CD8 which binds to the α3-domain of the MHC class Ia molecule. This antibody, raised against antigens from Ginbuna carp, permits flow cytometric and immunofluorescence analysis of CD8α T cytotoxic cells from zebrafish, goldfish and the cyprinid fish carp.

Source: Dr. Teruyuki Nakanishi, Department of Veterinary Medicine, Faculty of Materials Science and Technology, University of Japan

References:
1) Toda H., et al. Allo-antigen specific killing is mediated by CD8 positive T cells in fish. Dev. Comp. Immunol. (2009) 33 (4), 646-652.
2) Shibasaki Y., et al. Kinetics of lymphoid subpopulations in allogeneic grafted scales of ginbuna crucian carp. Dev Comp Immunol. (2015) 52 (1), 75-80.