Monoclonal Antibody of 100 μg targeting caspase-8 for WB.
| Product Specifications | |
| Application | WB |
| Reactivity | Human |
| Clonality | Monoclonal IgG2b |
| Host | Mouse |
| Immunogen | Recombinant human Caspase-8 (:176-460 aa terminal C) |
| Gene ID - Human | |
| Gene ID - Mouse | |
| Formulation | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Citations for Anti-Caspase-8 (Human) mAb (Clone: 5F7) – 21 Found |
| Eguchi, Y; Srinivasan, A; Tomaselli, K J; Shimizu, S; Tsujimoto, Y. ATP-dependent steps in apoptotic signal transduction. Cancer Research. 1999;59(9):2174-81. PubMed - Comments: Used in: WB |
| Imai, Y; Kimura, T; Murakami, A; Yajima, N; Sakamaki, K; Yonehara, S. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature. 1999;398(6730):777-85. PubMed - Comments: Used in: WB |
| Migita, K; Yamasaki, S; Kita, M; Ida, H; Shibatomi, K; Kawakami, A; Aoyagi, T; Eguchi, K. Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3. Immunology. 2001;103(3):362-7. PubMed - Comments: Used in: WB |
| Nakayama, Masafumi; Ishidoh, Kazumi; Kayagaki, Nobuhiko; Kojima, Yuko; Yamaguchi, Noriko; Nakano, Hiroyasu; Kominami, Eiki; Okumura, Ko; Yagita, Hideo. Multiple pathways of TWEAK-induced cell death. Journal Of Immunology (Baltimore, Md. : 1950). 2002;168(2):734-43. PubMed - Comments: Used in: WB |
| Imamura, Ryu; Konaka, Kenji; Matsumoto, Norihiko; Hasegawa, Mizuho; Fukui, Masayuki; Mukaida, Naofumi; Kinoshita, Takeshi; Suda, Takashi. Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha. The Journal Of Biological Chemistry. 2004;279(45):46415-23. PubMed - Comments: Used in: WB |
| Hasegawa, Mizuho; Imamura, Ryu; Kinoshita, Takeshi; Matsumoto, Norihiko; Masumoto, Junya; Inohara, Naohiro; Suda, Takashi. ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. The Journal Of Biological Chemistry. 2005;280(15):15122-30. PubMed - Comments: Used in: WB |
| Hasegawa, Mizuho; Imamura, Ryu; Kinoshita, Takeshi; Matsumoto, Norihiko; Masumoto, Junya; Inohara, Naohiro; Suda, Takashi. ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. The Journal Of Biological Chemistry. 2005;280(15):15122-30. PubMed - Comments: Used in: IF |
| Ohgushi, Masatoshi; Kuroki, Shunsuke; Fukamachi, Hiroshi; O'Reilly, Lorraine A; Kuida, Keisuke; Strasser, Andreas; Yonehara, Shin. Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Molecular And Cellular Biology. 2005;25(22):10017-28. PubMed - Comments: Used in: WB |
| Okamoto, Kazuo; Fujisawa, Jun-ichi; Reth, Michael; Yonehara, Shin. Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB. Genes To Cells : Devoted To Molecular & Cellular Mechanisms. 2006;11(2):177-91. PubMed - Comments: Used in: WB |
| Stagni, Venturina; di Bari, Maria Giovanna; Cursi, Silvia; Condò, Ivano; Cencioni, Maria Teresa; Testi, Roberto; Lerenthal, Yaniv; Cundari, Enrico; Barilà, Daniela. ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. Blood. 2008;111(2):829-37. PubMed - Comments: Used in: WB |
| Inaba, Susumu; Eguchi, Tadashi; Motegi, Atsushi; Mizoue, Kazutoshi; Usui, Takeo; Nagai, Kazuo; Kataoka, Takao. The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells. The Journal Of Antibiotics. 2009;62(9):507-12. PubMed - Comments: Used in: WB |
| Liu, Juan; Uematsu, Hiroshi; Tsuchida, Nobuo; Ikeda, Masa-Aki. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Molecular Cancer. 2011;10:95. PubMed - Comments: Used in: WB |
| Estornes, Y; Toscano, F; Virard, F; Jacquemin, G; Pierrot, A; Vanbervliet, B; Bonnin, M; Lalaoui, N; Mercier-Gouy, P; Pachéco, Y; Salaun, B; Renno, T; Micheau, O; Lebecque, S. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death And Differentiation. 2012;19(9):1482-94. PubMed - Comments: Used in: WB |
| Horie, Nobuyuki; Hirabayashi, Naomi; Takahashi, Yoshie; Miyauchi, Yuko; Taguchi, Hiroko; Takeishi, Keiichi. Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biological & Pharmaceutical Bulletin. 2005;28(4):574-9. PubMed - Comments: Used in: WB |
| Caro-Maldonado, A; Tait, S W G; Ramírez-Peinado, S; Ricci, J-E; Fabregat, I; Green, D R; Muñoz-Pinedo, C. Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death And Differentiation. 2010;17(8):1335-44. PubMed - Comments: Used in: WB |
| Maas, C; Tromp, J M; van Laar, J; Thijssen, R; Elias, J A; Malara, A; Krippner-Heidenreich, A; Silke, J; van Oers, M Hj; Eldering, E. CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex. Cell Death & Disease. 2013;4(8):e782. PubMed - Comments: Used in: WB |
| Orme, Mariam H; Liccardi, Gianmaria; Moderau, Nina; Feltham, Rebecca; Wicky-John, Sidonie; Tenev, Tencho; Aram, Lior; Wilson, Rebecca; Bianchi, Katiuscia; Morris, Otto; Monteiro Domingues, Celia; Robertson, David; Tare, Meghana; Wepf, Alexander; Williams, David; Bergmann, Andreas; Gstaiger, Matthias; Arama, Eli; Ribeiro, Paulo S; Meier, Pascal. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nature Communications. 2016;7:10972. PubMed - Comments: Used in: WB |
| Glab, Jason A; Doerflinger, Marcel; Nedeva, Christina; Jose, Irvin; Mbogo, George W; Paton, James C; Paton, Adrienne W; Kueh, Andrew J; Herold, Marco J; Huang, David Cs; Segal, David; Brumatti, Gabriella; Puthalakath, Hamsa. DR5 and caspase-8 are dispensable in ER stress-induced apoptosis. Cell Death And Differentiation. 2017;24(5):944-950. PubMed - Comments: Used in: WB |
| Ohsugi, Tomoyuki; Yamaguchi, Kiyoshi; Zhu, Chi; Ikenoue, Tsuneo; Furukawa, Yoichi. Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells. Oncotarget. 2017;8(59):100176-100186. PubMed - Comments: Used in: WB |
| Dubuisson, Agathe; Favreau, Cécile; Fourmaux, Eric; Lareure, Sabrina; Rodrigues-Saraiva, Rafael; Pellat-Deceunynck, Catherine; El Alaoui, Said; Micheau, Olivier. Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. Cell Death & Disease. 2019;10(2):101. PubMed - Comments: Used in: WB |
| Elmallah, Mohammed I Y; Cogo, Sheron; Constantinescu, Andrei A; Elifio-Esposito, Selene; Abdelfattah, Mohammed S; Micheau, Olivier. Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP. Cells. 2020;9(8) PubMed - Comments: Used in: WB |