Anti CASP3 mAb (Clone 6B2)

CUSABIO

Catalog No: CSB-RA833808A0HU-50

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Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Product Specifications

• Application: WB, IHC, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 6B2)