| Product Specifications | |
| Application | ICC, IP, WB |
| Reactivity | Human, Mouse, Rat, Hamster |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Full-length recombinant human Beclin 1 |
| Formulation | In PBS/50% glycerol, pH 7.2 |
| Citations for Anti-Beclin 1 (Human) pAb – 38 Found |
| Matsunaga, Kohichi; Morita, Eiji; Saitoh, Tatsuya; Akira, Shizuo; Ktistakis, Nicholas T; Izumi, Tetsuro; Noda, Takeshi; Yoshimori, Tamotsu. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. The Journal Of Cell Biology. 2010;190(4):511-21. PubMed - Comments: Used in: WB |
| Russo, R; Berliocchi, L; Adornetto, A; Varano, G P; Cavaliere, F; Nucci, C; Rotiroti, D; Morrone, L A; Bagetta, G; Corasaniti, M T. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death & Disease. 2011;2(4):e144. PubMed - Comments: Used in: WB |
| Russo, R; Berliocchi, L; Adornetto, A; Varano, G P; Cavaliere, F; Nucci, C; Rotiroti, D; Morrone, L A; Bagetta, G; Corasaniti, M T. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death & Disease. 2011;2(4):e144. PubMed - Comments: Used in: IHC |
| Berliocchi, Laura; Russo, Rossella; Maiarù, Maria; Levato, Alessandra; Bagetta, Giacinto; Corasaniti, Maria Tiziana. Autophagy impairment in a mouse model of neuropathic pain. Molecular Pain. 2011;7:83. PubMed - Comments: Used in: WB |
| Hamasaki, Maho; Furuta, Nobumichi; Matsuda, Atsushi; Nezu, Akiko; Yamamoto, Akitsugu; Fujita, Naonobu; Oomori, Hiroko; Noda, Takeshi; Haraguchi, Tokuko; Hiraoka, Yasushi; Amano, Atsuo; Yoshimori, Tamotsu. Autophagosomes form at ER-mitochondria contact sites. Nature. 2013;495(7441):389-93. PubMed - Comments: Used in: WB |
| Chen, Xiaojuan; Wang, Kai; Xing, Yaling; Tu, Jian; Yang, Xingxing; Zhao, Qian; Li, Kui; Chen, Zhongbin. Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity. Protein & Cell. 2014;5(12):912-27. PubMed - Comments: Used in: WB |
| Liu, Meng-Ling; Wang, Jing-Lei; Wei, Jie; Xu, Lin-Lin; Yu, Mei; Liu, Xiao-Mei; Ruan, Wen-Li; Chen, Jia-Xiang. Tri-ortho-cresyl phosphate induces autophagy of rat spermatogonial stem cells. Reproduction (Cambridge, England). 2015;149(2):163-70. PubMed - Comments: Used in: WB |
| Russo, Rossella; Cassiano, Maria Gilda Valentina; Ciociaro, Antonella; Adornetto, Annagrazia; Varano, Giuseppe Pasquale; Chiappini, Carlotta; Berliocchi, Laura; Tassorelli, Cristina; Bagetta, Giacinto; Corasaniti, Maria Tiziana. Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells. Plos One. 9(11):e113682. PubMed - Comments: Used in: WB |
| Munson, Michael J; Allen, George Fg; Toth, Rachel; Campbell, David G; Lucocq, John M; Ganley, Ian G. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. The Embo Journal. 2015;34(17):2272-90. PubMed - Comments: Used in: WB |
| Lin, Shao Jian; Leng, Zhi Gen; Guo, Yu Hang; Cai, Lin; Cai, Yu; Li, Ning; Shang, Han Bing; Le, Wei-Dong; Zhao, Wei Guo; Wu, Zhe Bao. Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline. Oncotarget. 2015;6(36):39329-41. PubMed - Comments: Used in: WB |
| Fujiwara, Nobuyuki; Usui, Tatsuya; Ohama, Takashi; Sato, Koichi. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). The Journal Of Biological Chemistry. 2016;291(20):10858-66. PubMed - Comments: Used in: WB |
| Wei, Zong-Bo; Yuan, Ye-Feng; Jaouen, Florence; Ma, Mei-Sheng; Hao, Chan-Juan; Zhang, Zhe; Chen, Quan; Yuan, Zengqiang; Yu, Li; Beurrier, Corinne; Li, Wei. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. 2016;12(7):1168-79. PubMed - Comments: Used in: WB |
| Wei, Zong-Bo; Yuan, Ye-Feng; Jaouen, Florence; Ma, Mei-Sheng; Hao, Chan-Juan; Zhang, Zhe; Chen, Quan; Yuan, Zengqiang; Yu, Li; Beurrier, Corinne; Li, Wei. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. 2016;12(7):1168-79. PubMed - Comments: Used in: IP |
| Liu, Xiaomei; Xu, Linlin; Shen, Jingcao; Wang, Jinglei; Ruan, Wenli; Yu, Mei; Chen, Jiaxiang. Involvement of oxidative stress in tri-ortho-cresyl phosphate-induced autophagy of mouse Leydig TM3 cells in vitro. Reproductive Biology And Endocrinology : Rb&E. 2016;14(1):30. PubMed - Comments: Used in: WB |
| Li, Si; Zhang, Hai-Yan; Du, Zhen-Xian; Li, Chao; An, Ming-Xin; Zong, Zhi-Hong; Liu, Bao-Qin; Wang, Hua-Qin. Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells. Oncotarget. 2016;7(43):70364-70377. PubMed - Comments: Used in: WB |
| Watanabe, Yuichiro; Honda, Shinya; Konishi, Akimitsu; Arakawa, Satoko; Murohashi, Michiko; Yamaguchi, Hirofumi; Torii, Satoru; Tanabe, Minoru; Tanaka, Shinji; Warabi, Eiji; Shimizu, Shigeomi. Autophagy controls centrosome number by degrading Cep63. Nature Communications. 2016;7:13508. PubMed - Comments: Used in: WB |
| Wakatsuki, Shuji; Tokunaga, Shinji; Shibata, Megumi; Araki, Toshiyuki. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. The Journal Of Cell Biology. 2017;216(2):477-493. PubMed - Comments: Used in: WB |
| Wakatsuki, Shuji; Tokunaga, Shinji; Shibata, Megumi; Araki, Toshiyuki. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. The Journal Of Cell Biology. 2017;216(2):477-493. PubMed - Comments: Used in: IP |
| An, Lin; Hu, Xiao-Wen; Zhang, Shasha; Hu, Xiaowen; Song, Zongpei; Naz, Amber; Zi, Zhenguo; Wu, Jian; Li, Can; Zou, Yunzeng; He, Lin; Zhu, Hongxin. UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity. Scientific Reports. 2017;7:43251. PubMed - Comments: Used in: WB |
| Arasaki, Kohei; Mikami, Yumi; Shames, Stephanie R; Inoue, Hiroki; Wakana, Yuichi; Tagaya, Mitsuo. Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17. Nature Communications. 2017;8:15406. PubMed - Comments: Used in: WB |
| Zhao, Zhiwei; Li, Xiaoling; Li, Qing. Curcumin accelerates the repair of sciatic nerve injury in rats through reducing Schwann cells apoptosis and promoting myelinization. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2017;92:1103-1110. PubMed - Comments: Used in: WB |
| Fujiwara, Mitsuhiro; Iwata, Masahiro; Inoue, Takayuki; Aizawa, Yosuke; Yoshito, Natsumi; Hayashi, Kazuhiro; Suzuki, Shigeyuki. Decreased grip strength, muscle pain, and atrophy occur in rats following long-term exposure to excessive repetitive motion. Febs Open Bio. 2017;7(11):1737-1749. PubMed - Comments: Used in: WB |
| Han, Yudi; Zhang, Lihai; Xing, Yaling; Zhang, Licheng; Chen, Xiaojuan; Tang, Peifu; Chen, Zhongbin. Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid. International Journal Of Molecular Medicine. 2018;41(2):800-808. PubMed - Comments: Used in: WB |
| Li, Miao; Li, Jian; Zeng, Ruihong; Yang, Jianling; Liu, Jianguo; Zhang, Zhengzheng; Song, Xiaotian; Yao, Zhiyan; Ma, Cuiqing; Li, Wenjian; Wang, Kai; Wei, Lin. Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. Journal Of Virology. 2018;92(8) PubMed - Comments: Used in: WB |
| Lin, Xin; Cui, Ming; Xu, Dong; Hong, Dubeiqi; Xia, Yan; Xu, Chentong; Li, Riyong; Zhang, Xuan; Lou, Yaxin; He, Qihua; Lv, Ping; Chen, Yingyu. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death & Disease. 2018;9(7):768. PubMed - Comments: Used in: WB |
| Zhang, Yun; Tang, Hongmei; Yuan, Xiefang; Ran, Qin; Wang, Xiaoyun; Song, Qi; Zhang, Lei; Qiu, Yuhuan; Wang, Xing. TGF-β3 Promotes MUC5AC Hyper-Expression by Modulating Autophagy Pathway in Airway Epithelium. Ebiomedicine. 2018;33:242-252. PubMed - Comments: Used in: WB |
| Hagio-Izaki, Kanako; Yasunaga, Madoka; Yamaguchi, Masahiro; Kajiya, Hiroshi; Morita, Hiromitsu; Yoneda, Masahiro; Hirofuji, Takao; Ohno, Jun. Lipopolysaccharide induces bacterial autophagy in epithelial keratinocytes of the gingival sulcus. Bmc Cell Biology. 2018;19(1):18. PubMed - Comments: Used in: WB |
| Jin, Gui-Lin; Yue, Rong-Cai; He, Sai-di; Hong, Li-Mian; Xu, Ying; Yu, Chang-Xi. Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats. Frontiers In Pharmacology. 9:989. PubMed - Comments: Used in: WB |
| Wang, Min; Tang, Changyong; Xing, Ruxiao; Liu, Xuezhao; Han, Xiu; Liu, Yinghao; Wang, Lei; Yang, Chonglin; Guo, Weixiang. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Molecular Psychiatry. 2021;26(2):694-709. PubMed - Comments: Used in: WB |
| Wang, Min; Tang, Changyong; Xing, Ruxiao; Liu, Xuezhao; Han, Xiu; Liu, Yinghao; Wang, Lei; Yang, Chonglin; Guo, Weixiang. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Molecular Psychiatry. 2021;26(2):694-709. PubMed - Comments: Used in: IP |
| Sase, Kana; Kitaoka, Yasushi; Tsukahara, Chihiro; Takagi, Hitoshi. Involvement of Beclin‑1 in axonal protection by short‑term hyperglycemia against TNF‑induced optic nerve damage. Molecular Medicine Reports. 2018;18(6):5455-5460. PubMed - Comments: Used in: WB |
| Sase, Kana; Kitaoka, Yasushi; Tsukahara, Chihiro; Takagi, Hitoshi. Involvement of Beclin‑1 in axonal protection by short‑term hyperglycemia against TNF‑induced optic nerve damage. Molecular Medicine Reports. 2018;18(6):5455-5460. PubMed - Comments: Used in: IHC |
| Noguchi, Saori; Honda, Shinya; Saitoh, Tatsuya; Matsumura, Hiroyuki; Nishimura, Emi; Akira, Shizuo; Shimizu, Shigeomi. Beclin 1 regulates recycling endosome and is required for skin development in mice. Communications Biology. 2:37. PubMed - Comments: Used in: WB |
| Nakajima, Shinsuke; Nishimoto, Yuki; Tateya, Sanshiro; Iwahashi, Yasuyuki; Okamatsu-Ogura, Yuko; Saito, Masayuki; Ogawa, Wataru; Tamori, Yoshikazu. Fat-specific protein 27α inhibits autophagy-dependent lipid droplet breakdown in white adipocytes. Journal Of Diabetes Investigation. 2019;10(6):1419-1429. PubMed - Comments: Used in: WB |
| Shen, Jingcao; Yang, Dan; Zhou, Xingfan; Wang, Yuqian; Tang, Shichuan; Yin, Hong; Wang, Jinglei; Chen, Rui; Chen, Jiaxiang. Role of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells. International Journal Of Molecular Sciences. 2019;20(16) PubMed - Comments: Used in: WB |
| Jiang, Li-Jun; Xu, Zhen-Xing; Wu, Ming-Fu; Dong, Gai-Qin; Zhang, Li-Li; Gao, Jun-Yan; Feng, Chen-Xi; Feng, Xing. Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats. Neural Regeneration Research. 2020;15(7):1316-1325. PubMed - Comments: Used in: WB |
| Fujiwara, Nobuyuki; Shibutani, Shusaku; Sakai, Yusuke; Watanabe, Toshio; Kitabayashi, Issay; Oshima, Hiroko; Oshima, Masanobu; Hoshida, Hisashi; Akada, Rinji; Usui, Tatsuya; Ohama, Takashi; Sato, Koichi. Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6. Cancer Science. 2020;111(12):4371-4380. PubMed - Comments: Used in: WB |
| Mizutani, Yasuaki; Maeda, Toshiki; Murate, Kenichiro; Ito, Shinji; Watanabe, Hirohisa; Mutoh, Tatsuro. Clioquinol kills astrocyte-derived KT-5 cells by the impairment of the autophagy-lysosome pathway. Archives Of Toxicology. 2021;95(2):631-640. PubMed - Comments: Used in: WB |