Anti APOL1 pAb (ATL-HPA018885 w/enhanced validation)

Atlas

Catalog No: ATL-HPA018885-25

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Application: WB, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: apolipoprotein L, 1
Gene Name: APOL1
Alternative Gene Name: APOL
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000010601: 43%, ENSRNOG00000047782: 39%
Entrez Gene ID: 8542
Uniprot ID: O14791
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti APOL1 pAb (ATL-HPA018885 w/enhanced validation) – 28 Found

Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.
J Am Soc Nephrol. 2015 Feb;26(2):339-48. doi: 10.1681/ASN.2013091017. Epub 2014 Jul 10. 

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1.
Am J Physiol Cell Physiol. 2015 Jul 1;309(1):C22-37. doi: 10.1152/ajpcell.00384.2014. Epub 2015 Apr 29. 

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.
J Lipid Res. 2015 Aug;56(8):1583-93. doi: 10.1194/jlr.M059733. Epub 2015 Jun 18. 

BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins.
Am J Physiol Cell Physiol. 2015 Sep 1;309(5):C332-47. doi: 10.1152/ajpcell.00142.2015. Epub 2015 Jun 24. 

APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes.
J Am Soc Nephrol. 2017 Apr;28(4):1117-1130. doi: 10.1681/ASN.2016050546. Epub 2016 Nov 18. 

A tripartite complex of suPAR, APOL1 risk variants and α(v)β(3) integrin on podocytes mediates chronic kidney disease.
Nat Med. 2017 Aug;23(8):945-953. doi: 10.1038/nm.4362. Epub 2017 Jun 26. 

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion.
J Am Soc Nephrol. 2017 Nov;28(11):3227-3238. doi: 10.1681/ASN.2016111220. Epub 2017 Jul 10. 

APOLs with low pH dependence can kill all African trypanosomes.
Nat Microbiol. 2017 Nov;2(11):1500-1506. doi: 10.1038/s41564-017-0034-1. Epub 2017 Sep 18. 

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.
Commun Biol. 2018 Nov 7;1:188. doi: 10.1038/s42003-018-0188-2. eCollection 2018. 

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3712-3721. doi: 10.1073/pnas.1820414116. Epub 2019 Feb 7. 

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.
PLoS One. 2019 Apr 18;14(4):e0211559. doi: 10.1371/journal.pone.0211559. eCollection 2019. 

Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
J Am Soc Nephrol. 2020 Sep;31(9):2044-2064. doi: 10.1681/ASN.2019080829. Epub 2020 Aug 6. 

APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis.
Hum Mol Genet. 2021 Apr 26;30(3-4):182-197. doi: 10.1093/hmg/ddab022. 

Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys.
PLoS One. 2021 Jun 17;16(6):e0253197. doi: 10.1371/journal.pone.0253197. eCollection 2021. 

Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects.
Mol Biol Evol. 2021 Oct 27;38(11):4962-4976. doi: 10.1093/molbev/msab220. 

Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity.
iScience. 2021 Dec 31;25(1):103717. doi: 10.1016/j.isci.2021.103717. eCollection 2022 Jan 21. 

Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells.
Cancers (Basel). 2022 Jan 30;14(3):733. doi: 10.3390/cancers14030733. 

APOL1 localization in normal kidney and nondiabetic kidney disease.
J Am Soc Nephrol. 2011 Nov;22(11):2119-28. doi: 10.1681/ASN.2011010069. Epub 2011 Oct 13. 

APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis.
PLoS One. 2012;7(12):e51546. doi: 10.1371/journal.pone.0051546. Epub 2012 Dec 26. 

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.
Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20. 

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy.
Nephrol Dial Transplant. 2018 Feb 1;33(2):323-330. doi: 10.1093/ndt/gfw451. 

Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch.
Sci Rep. 2018 Jun 7;8(1):8739. doi: 10.1038/s41598-018-27104-x. 

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice.
JCI Insight. 2019 Jun 20;4(12):e126124. doi: 10.1172/jci.insight.126124. eCollection 2019 Jun 20. 

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.
J Am Soc Nephrol. 2019 Dec;30(12):2355-2368. doi: 10.1681/ASN.2019020114. Epub 2019 Sep 26. 

Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway.
Sci Rep. 2019 Oct 29;9(1):15485. doi: 10.1038/s41598-019-51998-w. 

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Cell Rep. 2020 Mar 17;30(11):3821-3836.e13. doi: 10.1016/j.celrep.2020.02.064. 

Profiling APOL1 Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell Transcriptomics.
Kidney360. 2020 Mar;1(3):203-215. doi: 10.34067/kid.0000422019. 

Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease.
Dis Model Mech. 2021 Aug 1;14(8):dmm048952. doi: 10.1242/dmm.048952. Epub 2021 Aug 5.