Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
| Product Specifications | |
| Application | IHC, ELISA |
| Reactivity | Human |
| Clonality | Monoclonal (Clone No.: 1F10) |
| Documents & Links for Anti ANGPT2 mAb (Clone 1F10) | |
| Datasheet | Anti ANGPT2 mAb (Clone 1F10) Datasheet |
| Vendor Page | Anti ANGPT2 mAb (Clone 1F10) at CUSABIO |
| Documents & Links for Anti ANGPT2 mAb (Clone 1F10) | |
| Datasheet | Anti ANGPT2 mAb (Clone 1F10) Datasheet |
| Vendor Page | Anti ANGPT2 mAb (Clone 1F10) |