Application: IHC, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Documents & Links for Anti ANGPT2 mAb (Clone 1F10) | |
Datasheet | Anti ANGPT2 mAb (Clone 1F10) Datasheet |
Vendor Page | Anti ANGPT2 mAb (Clone 1F10) at CUSABIO |
Documents & Links for Anti ANGPT2 mAb (Clone 1F10) | |
Datasheet | Anti ANGPT2 mAb (Clone 1F10) Datasheet |
Vendor Page | Anti ANGPT2 mAb (Clone 1F10) |