Aggrus (T1 alpha /Podoplanin) is a novel 36-45 kDa membrane sialoglycoprotein that induces platelet aggregation. Aggrus is highly expressed in various tumor cells and the platelet aggregation ability of Aggrus depends on specific oligosaccharide structures that may be related to the metastasis process in cancer cells. Aggrus has been identified as a diagnostic tumor marker for seminomas and testicular cancers.
Monoclonal antibody of 100 μg targeting PDPN for FCM, IHC, IPP, WB.
| Product Specifications | |
| Application | FC, IP, WB, IHC |
| Reactivity | Mouse |
| Clonality | Monoclonal IgG2a |
| Host | Rat |
| Immunogen | NL-17 cell membrane fractions |
| Formulation | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Citations for Anti-Aggrus (Podoplanin) (Mouse) mAb (Clone: 8F11) – 7 Found |
| Fu, Jianxin; Gerhardt, Holger; McDaniel, J Michael; Xia, Baoyun; Liu, Xiaowei; Ivanciu, Lacramioara; Ny, Annelii; Hermans, Karlien; Silasi-Mansat, Robert; McGee, Samuel; Nye, Emma; Ju, Tongzhong; Ramirez, Maria I; Carmeliet, Peter; Cummings, Richard D; Lupu, Florea; Xia, Lijun. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. The Journal Of Clinical Investigation. 2008;118(11):3725-37. PubMed - Comments: Used in: ICC |
| Lapinski, Philip E; Kwon, Sunkuk; Lubeck, Beth A; Wilkinson, John E; Srinivasan, R Sathish; Sevick-Muraca, Eva; King, Philip D. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. The Journal Of Clinical Investigation. 2012;122(2):733-47. PubMed - Comments: Used in: FCM |
| Kallert, Sandra M; Darbre, Stephanie; Bonilla, Weldy V; Kreutzfeldt, Mario; Page, Nicolas; Müller, Philipp; Kreuzaler, Matthias; Lu, Min; Favre, Stéphanie; Kreppel, Florian; Löhning, Max; Luther, Sanjiv A; Zippelius, Alfred; Merkler, Doron; Pinschewer, Daniel D. Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy. Nature Communications. 2017;8:15327. PubMed - Comments: Used in: IHC |
| Chida, Junji; Hara, Hideyuki; Yano, Masashi; Uchiyama, Keiji; Das, Nandita Rani; Takahashi, Etsuhisa; Miyata, Hironori; Tomioka, Yukiko; Ito, Toshihiro; Kido, Hiroshi; Sakaguchi, Suehiro. Prion protein protects mice from lethal infection with influenza A viruses. Plos Pathogens. 2018;14(5):e1007049. PubMed - Comments: Used in: WB |
| Chida, Junji; Hara, Hideyuki; Yano, Masashi; Uchiyama, Keiji; Das, Nandita Rani; Takahashi, Etsuhisa; Miyata, Hironori; Tomioka, Yukiko; Ito, Toshihiro; Kido, Hiroshi; Sakaguchi, Suehiro. Prion protein protects mice from lethal infection with influenza A viruses. Plos Pathogens. 2018;14(5):e1007049. PubMed - Comments: Used in: IHC |
| Kadowaki, Hisae; Satrimafitrah, Pasjan; Takami, Yasunari; Nishitoh, Hideki. Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. Scientific Reports. 2018;8(1):7317. PubMed - Comments: Used in: WB |
| Chida, Junji; Hara, Hideyuki; Uchiyama, Keiji; Takahashi, Etsuhisa; Miyata, Hironori; Kosako, Hidetaka; Tomioka, Yukiko; Ito, Toshihiro; Horiuchi, Hiroyuki; Matsuda, Haruo; Kido, Hiroshi; Sakaguchi, Suehiro. Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice. Plos Pathogens. 2020;16(8):e1008823. PubMed - Comments: Used in: WB |