Anti ACE2 pAb (ATL-HPA000288 w/enhanced validation)

Atlas

Catalog No: ATL-HPA000288-100

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Application: WB, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: angiotensin I converting enzyme 2
Gene Name: ACE2
Alternative Gene Name:
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000015405: 74%, ENSRNOG00000031665: 46%
Entrez Gene ID: 59272
Uniprot ID: Q9BYF1
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti ACE2 pAb (ATL-HPA000288 w/enhanced validation) – 35 Found

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.
Immunity. 2021 Sep 14;54(9):2143-2158.e15. doi: 10.1016/j.immuni.2021.08.015. Epub 2021 Aug 18. 

Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.
Fertil Steril. 2021 Dec;116(6):1631-1640. doi: 10.1016/j.fertnstert.2021.08.009. Epub 2021 Aug 11. 

Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model.
PLoS Pathog. 2021 Oct 14;17(10):e1009542. doi: 10.1371/journal.ppat.1009542. eCollection 2021 Oct. 

ACE2 Protein Expression During Childhood, Adolescence, and Early Adulthood.
Pediatr Dev Pathol. 2022 Jul-Aug;25(4):404-408. doi: 10.1177/10935266221075312. Epub 2022 Feb 28. 

Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease.
Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L712-L721. doi: 10.1152/ajplung.00305.2021. Epub 2022 Mar 23. 

Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium.
Nat Commun. 2022 Mar 25;13(1):1609. doi: 10.1038/s41467-022-29255-y. 

Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer.
Gastroenterology. 2010 Jul;139(1):213-25.e3. doi: 10.1053/j.gastro.2010.04.008. Epub 2010 Apr 13. 

Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model.
Proteome Sci. 2011 Nov 17;9:73. doi: 10.1186/1477-5956-9-73. 

Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice.
Physiol Rep. 2020 Feb;8(3):e14364. doi: 10.14814/phy2.14364. 

A profiling analysis on the receptor ACE2 expression reveals the potential risk of different type of cancers vulnerable to SARS-CoV-2 infection.
Ann Transl Med. 2020 Apr;8(7):481. doi: 10.21037/atm.2020.03.61. 

Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19.
Mol Biol Rep. 2020 Jun;47(6):4383-4392. doi: 10.1007/s11033-020-05478-4. Epub 2020 May 14. 

Low baseline pulmonary levels of cytotoxic lymphocytes as a predisposing risk factor for severe COVID-19.
bioRxiv [Preprint]. 2020 Jul 31:2020.05.04.075291. doi: 10.1101/2020.05.04.075291. 

Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
medRxiv [Preprint]. 2020 May 12:2020.05.08.20092866. doi: 10.1101/2020.05.08.20092866. 

The protein expression profile of ACE2 in human tissues.
Mol Syst Biol. 2020 Jul;16(7):e9610. doi: 10.15252/msb.20209610. 

Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients.
Int J Biol Sci. 2020 Jul 6;16(13):2464-2476. doi: 10.7150/ijbs.48639. eCollection 2020. 

Secukinumab lowers expression of ACE2 in affected skin of patients with psoriasis.
J Allergy Clin Immunol. 2021 Mar;147(3):1107-1109.e2. doi: 10.1016/j.jaci.2020.09.021. Epub 2020 Sep 28. 

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
PLoS One. 2020 Oct 28;15(10):e0240647. doi: 10.1371/journal.pone.0240647. eCollection 2020. 

ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Nat Commun. 2020 Oct 28;11(1):5453. doi: 10.1038/s41467-020-19145-6. 

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities.
Elife. 2020 Nov 9;9:e61390. doi: 10.7554/eLife.61390. 

Acute Respiratory Distress in Aged, SARS-CoV-2-Infected African Green Monkeys but Not Rhesus Macaques.
Am J Pathol. 2021 Feb;191(2):274-282. doi: 10.1016/j.ajpath.2020.10.016. Epub 2020 Nov 7. 

Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Cell Metab. 2020 Dec 1;32(6):1041-1051.e6. doi: 10.1016/j.cmet.2020.11.005. Epub 2020 Nov 13. 

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.
Cell Metab. 2020 Dec 1;32(6):1028-1040.e4. doi: 10.1016/j.cmet.2020.11.006. Epub 2020 Nov 13. 

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.
EMBO J. 2021 Mar 1;40(5):e105912. doi: 10.15252/embj.2020105912. Epub 2021 Jan 11. 

A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019.
Ann Transl Med. 2020 Nov;8(21):1403. doi: 10.21037/atm-20-2755. 

Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
EMBO Mol Med. 2021 Apr 9;13(4):e13191. doi: 10.15252/emmm.202013191. Epub 2021 Mar 3. 

Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients.
Sci Rep. 2021 Feb 25;11(1):4533. doi: 10.1038/s41598-021-83366-y. 

Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension.
Front Pharmacol. 2021 Jan 29;11:602985. doi: 10.3389/fphar.2020.602985. eCollection 2020. 

Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection.
Ther Adv Med Oncol. 2021 Apr 29;13:17588359211011455. doi: 10.1177/17588359211011455. eCollection 2021. 

Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues.
Sci Rep. 2021 Sep 27;11(1):19140. doi: 10.1038/s41598-021-98709-y. 

Comprehensive Analysis of Disease Pathology in Immunocompetent and Immunocompromised Hosts following Pulmonary SARS-CoV-2 Infection.
Biomedicines. 2022 Jun 7;10(6):1343. doi: 10.3390/biomedicines10061343. 

Spike protein of SARS-CoV-2 suppresses gonadotrophin secretion from bovine anterior pituitaries.
J Reprod Dev. 2022 Apr 1;68(2):152-159. doi: 10.1262/jrd.2021-126. Epub 2022 Jan 27. 

Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination.
Intern Med. 2022 Aug 1;61(15):2319-2325. doi: 10.2169/internalmedicine.9800-22. Epub 2022 May 31. 

SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma.
PLoS One. 2023 Jan 3;18(1):e0279578. doi: 10.1371/journal.pone.0279578. eCollection 2023. 

Higher Angiotensin I Converting Enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease.
bioRxiv [Preprint]. 2023 Jan 18:2023.01.17.524254. doi: 10.1101/2023.01.17.524254. 

Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium.
Mucosal Immunol. 2023 Feb;16(1):5-16. doi: 10.1016/j.mucimm.2022.12.001. Epub 2023 Jan 13.