Alpha-Synuclein, Recombinant, Human

Cosmo Bio LTD

Catalog No: CSR-SYN04-2

Visit our Neurodegeneration Products homepage to browse related research products

Click here for the Neuroscience Products Dashboard Page

E. coli expressed human α-synuclein has been widely used in structural and functional studies. Masuda et. al. (1)  have reported that approximately 20% of E. coli expressed human α-syn is mistranslated resulting in a Cys residue instead of Tyr at position 136 and causing an increase in the levels of dimeric α-synuclein.

CSR-SYN04 is E. coli human alpha-Synuclein (human) expressed from a plasmid in which the TAC codon coding for Tyr136 in the human protein is replaced by TAT to produce protein expressing Tyr at position 136 homogenously. It can be used as human α-syn under similar conditions to that of in vivo.

This product can also be used for comparison (control) of α-Synuclein Fibrils (CSR-SYN03).

Source: Human
Expression System: E.coli
Concentration: 1mg/mL
Purity: ≥ 90% (SDS-Page)
Storage: -20°C

(1) Masuda M, Dohmae N, Nonaka T, Oikawa T, Hisanaga S, Goedert M, Hasegawa M. Cysteine misincorporation in bacterially expressed human alpha-synuclein. FEBS Lett. 2006 Mar 20;580(7):1775-9. doi: 10.1016/j.febslet.2006.02.032. Epub 2006 Feb 24. PMID: 16513114.

Related Products

Product	Cat. No.
Alpha-Synuclein Aggregation Assay Kit	CSR-SYN01
Amyloid Fluorescent Staining Kit	CSR-SYN02
Alpha-Synuclein Fibrils, Human	CSR-SYN03
Alpha-Synuclein, Human	CSR-SYN04
Alpha-Synuclein Fibrils, Mouse	CSR-SYN05
Alpha-Synuclein, Recombinant, Mouse	CSR-SYN06