Other Tetramers

CD1d is a membrane protein non-covalently bonded to ß2-microglobulin (ß2m) and shows high homology between human and mice. CD1d can present a-galactosylceramide (a-GalCer), a glycolipid extracted and isolated from the marine sponge, and this complex can activate human and murine CD1drestricted NKT cells. CD1d Tetramer-PE is a reagent prepared by tetramerization of complexes of CD1d and ß2m by PE- or APC- labeled streptavidin. Binding this reagent to a-GalCer enables highly sensitive detection of CD1d-restricted NKT cells and can be combined with antibodies to study NKT cell function by flow cytometry.

Reference:
1) Stephane S et al. J. Immunol. Methods 268, 107-121 (2002)
2) Matsuda JL et al. J. Exp. Med. 192, 741-754 (2000)
3) Benlagha K et al. J. Exp. Med. 191, 1895-1903 (2000)

 

 

Product Name (click for purchase info)	Species Reactivity	Target	Target location	Class	Locus	Allele	Sequence	Conjugate	Size	CBU Cat. No.
Non-Classical Tetramers:CD1d
T-Select Human CD1d Tetramer-SA-PE	Hu	NKT cells		CD1d			Unloaded	PE	50 tests	MBL-TS-HCD-1
T-Select Human CD1d Tetramer - APC	Hu	NKT cells		CD1d			Unloaded	APC	50 tests	MBL-TS-HCD-2
Human CD1d Tetramer (α-GalCer loaded)-PE	Hu	NKT cells		CD1d			α-GalCer loaded	PE	50 tests	MBL-TS-HCG-1
Human CD1d Tetramer (α-GalCer loaded)-APC	Hu	NKT cells		CD1d			α-GalCer loaded	APC	50 tests	MBL-TS-HCG-2
T-Select Mouse CD1d Tetramer-SA-PE	Ms	NKT cells		CD1d			Unloaded	PE	50 tests	MBL-TS-MCD-1
T-Select Mouse CD1d Tetramer - APC	Ms	NKT cells		CD1d			Unloaded	APC	50 tests	MBL-TS-MCD-2
Mouse CD1d Tetramer (α-GalCer loaded)-PE	Ms	NKT cells		CD1d			α-GalCer loaded	PE	50 tests	MBL-TS-MCG-1
Mouse CD1d Tetramer (α-GalCer loaded)-APC	Ms	NKT cells		CD1d			α-GalCer loaded	APC	50 tests	MBL-TS-MCG-2
T-Cell Receptor Tetramers
Human TCR Tetramer-PE (HLA-A*24:02 survivin-2B80-88-AYACNTSTL)	Hu	survivin 2B	(80-88)	TCR	HLA-A	24:02	AYACNTSTL	PE	500 ul	MBL-TS-TCR01-1
Human TCR Tetramer-PE (HLA-A*24:02 PBF145-153-AYRPVSRNI)	Hu	Papilloma Binding Factor	145-153	TCR	HLA-A	24:02	AYRPVSRNI	PE	500 ul	MBL-TS-TCR02-1