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CD91 (LRP1) antibody

For exosome research

LDL Receptor-Related Protein (LRP1, CD91)1) is a high-affinity endocytic receptor for myelin-associated glycoprotein (MAG)2) that binds to ligands and exhibits signaling properties3) and is known to play diverse roles in lipoprotein metabolism, protease degradation, lysosomal enzyme activation, and cellular entry of bacterial toxins and viruses4) .

CD91 (LRP1) has been shown to be a potential NSCLC (non-small cell lung cancer) exosome marker5) . Expression of CD91 (LRP1) is associated with improved outcome in lung cancer6) and agonists promote regeneration after spinal cord injury7).

Specification

  • Class : Monoclonal
  • Clone : B3-3E11
  • Isotype : IgG1κ
  • Immunogen : Human CD91 extracellular region-FLAG-rabbit Fc
  • Reactivity : Human
  • Purification : Affinity (Protein G)
  • Buffer : PBS, 0.1% NaN3
  • Application : WB, IS

Data

Immunocytochemistry of SJRH30 cell line
  • Sample: SJRH30 cell line
  • Primary antibody: anti-CD91 (B3-3E11) (10 ug/mL）
  • Secondary antibody: Anti-Mouse IgG-Alexa Fluor 488 (8 ug/mL）
  • Nuclear staining: Hoechst 33342 (Green: antibody, Blue: stained nucleus)

References

  1. Herz J, et al., EMBO J. 1988 Dec 20;7(13):4119-27. PMID: 3266596.
  2. Stiles TL, et al., J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. PMID: 23132925.
  3. Etique N, et al., Biomed Res Int. 2013:152163. PMID: 23936774
  4. Lillis AP, et al., J Thromb Haemost. 2005 Aug;3(8):1884-93. PMID: 16102056
  5. Huang SH, et al., Cancer Invest. 2013;31: 330?335. PMID: 23614656
  6. Meng H, et al., Clin Cancer Res. 2011 Apr 15;17(8):2426-33. PMID: 21325077
  7. Yoon C, et al., J Biol Chem. 2013 Sep 13;288(37):26557-68. PMID: 23867460

Product List

CD91 (LRP1) antibody

Product nameCatalog Number
Anti CD91 (LRP1), Human (Mouse) Unlabeled, B3-3E11 SHI-EXO-M04