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Atelogene® Live Mouse Transfection Kits

Atelogene® Local Use "Quick Gelation" 

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AteloGene® Local Use “Quick Gelation”

in vivo transfection kit is designed for delivering siRNA/miRNA into animal tissues, mouse in particular, to introduce the siRNA/miRNA into cells by local administrations.

About the Kit

Improved gel forming speed and transfection efficiency!!

This in vivo transfection kit is designed for delivering siRNA/miRNA into animal tissues, mouse in particular, to introduce the siRNA/miRNA into cells by local administrations.
Atelocollagen is positively charged and can thus electrostatically form complexes with nucleic acids when they are mixed together at appropriate concentrations and ratios. The complexes protect nucleic acids from being degraded by nucleases in in vivo.

What is Atelocollagen?


Applications

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Local administration of nucleic acids

Features

  • Prolonged in vivoRNAi effect because atelocollagen, the main component of AteloGene® products, form complexes with siRNA/miRNA
  • Since AteloGene® products are made from atelocollagen, it is nontoxic.
  • AteloGene® Local Use gelates in the body and siRNA/miRNA are slowly released from the gel at the site of administration.
  • AteloGene® Local Use “Quick Gelation” has been modified to increase in vivo transfection efficiency by focusing on faster gel formation at the site of administration.

Kit contents

Component Quantity
① AteloGene® Local Use “Quick Gelation” prefilled syringe
(Including losses during the preparation steps)		 540 μL × 3 syringes
②QG buffer 2.5 mL × 1 bottle
③2 mL microtube 4 tubes (A spare tube is included)
④18G needle 8 needles (2 spare needles are included)
⑤Instruction manual 1 leaflet

Due to the shortage of 2 mL microtubes, we will temporarily change to an alternative microtubes. There is no change in usage.

Devices and reagents required but not included in the kit

  • 1 mL disposable syringe
  • 27G needle
  • siRNA/miRNA (PAGE- or HPLC-purified grade is recommended.)
  • Container and water for preparation of siRNA/miRNA solution (sterilized, RNase-free)
  • Cooling device (crushed ice, cold block, etc.)
  • Tube rotator (that can tumble and agitate such as TAITEC RT-5, Bibby scientific SB3, etc.)
  • Pipetter and tips (sterilized, RNase-free)
  • High-speed refrigerated centrifuge
  • Anesthetic

Storage: 2-10°C  For research use only.

Click here for frequently asked questions about AteloGene® Local Use “Quick Gelation”

Experimental example

Local siRNA administration to mouse xenograft model with AteloGene® Local Use “Quick Gelation”.

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A remarkable reduction of luciferase expression was observed when a luciferase siRNA (Luc siRNA) was co-administered to dual-luciferase expressing melanoma xenograft mice with AteloGene® Local Use “Quick Gelation”.

References

Cancer

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    Gastroenterology. 2014 Jan;146(1):268-77.e18. PMID: 24120476
  • Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.
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    Cancer Sci. 2014 Oct;105(10):1351-9. PMID: 25098609
  • Paired box 2 upregulates androgen receptor gene expression in androgen-independent prostate cancer.
    Ito S, Ueda T, Ueno A, Nakagawa H, Taniguchi H, Hongo F, Kamoi K, Okihara K, Kawauchi A, Miki T.
    FEBS J. 2014 Oct;281(19):4506-18. PMID: 25132193
  • High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma.
    Jin J, Ryu HS, Lee KB, Jang JJ.
    PLoS One. 2014 Feb 28;9(2):e90247. PMID: 24587299
  • Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma.
    Migita K, Sho M, Shimada K, Yasuda S, Yamato I, Takayama T, Matsumoto S, Wakatsuki K, Hotta K, Tanaka T, Ito M, Konishi N, Nakajima Y.
    Cancer. 2014 Mar 15;120(6):808-17. PMID: 24249528
  • Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling.
    Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.
    J Biol Chem. 2014 Aug 8;289(32):21960-72. PMID: 24942731
  • miR-296/Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo.
    Savi F, Forno I, Faversani A, Luciani A, Caldiera S, Gatti S, Foa P, Ricca D, Bulfamante G, Vaira V, Bosari S.
    Clin Sci (Lond). 2014 Aug;127(4):233-42. PMID: 24527800
  • AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers.
    Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J.
    Cancer Med. 2014 Aug;3(4):759-74. PMID: 24723436
  • Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
    Takeuchi K, Yoshioka N, Higa Onaga S, Watanabe Y, Miyata S, Wada Y, Kudo C, Okada M, Ohko K, Oda K, Sato T, Yokoyama M, Matsushita N, Nakamura M, Okano H, Sakimura K, Kawano H, Kitagawa H, Igarashi M.
    Nat Commun. 2013;4:2740. PMID: 24220492
  • Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer.
    Endo H, Muramatsu T, Furuta M, Uzawa N, Pimkhaokham A, Amagasa T, Inazawa J, Kozaki K.
    Carcinogenesis. 2013 Mar;34(3):560-9. PMID: 23233740
  • Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.
    Fujiwara-Okada Y, Matsumoto Y, Fukushi J, Setsu N, Matsuura S, Kamura S, Fujiwara T, Iida K, Hatano M, Nabeshima A, Yamada H, Ono M, Oda Y, Iwamoto Y.
    Br J Cancer. 2013 Mar 5;108(4):836-47. PMID: 23462806
  • miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes.
    Hung PS, Liu CJ, Chou CS, Kao SY, Yang CC, Chang KW, Chiu TH, Lin SC.
    PLoS One. 2013 Nov 26;8(11):e79926. PMID: 24302991
    KAI?
  • Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation, Independent of its Hydrolase Activity.
    Kabuta T, Mitsui T, Takahashi M, Fujiwara Y, Kabuta C, Konya C, Tsuchiya Y, Hatanaka Y, Uchida K, Hohjoh H, Wada K.
    J Biol Chem. 2013 May 3;288(18):12615-26. PMID: 23543736
  • Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo.
    Kagawa Y, Matsumoto S, Kamioka Y, Mimori K, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M.
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  • In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer.
    Koyanagi T, Suzuki Y, Saga Y, Machida S, Takei Y, Fujiwara H, Suzuki M, Sato Y.
    Cancer Sci. 2013 Dec;104(12):1705-10. PMID: 24118388
  • Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia.
    Nomura T, Yamasaki M, Hirai K, Inoue T, Sato R, Matsuura K, Moriyama M, Sato F, Mimata H.
    Mol Cancer. 2013 Apr 8;12:27. PMID: 23566222
  • MicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer.
    Saito K, Inagaki K, Kamimoto T, Ito Y, Sugita T, Nakajo S, Hirasawa A, Iwamaru A, Ishikura T, Hanaoka H, Okubo K, Onozaki T, Zama T.
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  • YB-1 suppression induces STAT3 proteolysis and sensitizes renal cancer to interferon-α.
    Takeuchi A, Shiota M, Tatsugami K, Yokomizo A, Kuroiwa K, Dejima T, Tanaka S, Itsumi M, Eto M, Naito S.
    Cancer Immunol Immunother. 2013 Mar;62(3):517-27. PMID: 23052245
  • Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.
    Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, Araki A, Ohira M, Inoue M, Kageyama H, Yokoi S, Saeki N, Nakagawara A.
    Sci Rep. 2013;3:1160. PMID: 23362460
  • Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling.
    Kawamura S, Sato I, Wada T, Yamaguchi K, Li Y, Li D, Zhao X, Ueno S, Aoki H, Tochigi T, Kuwahara M, Kitamura T, Takahashi K, Moriya S, Miyagi T.
    Cell Death Differ. 2012 Jan;19(1):170-9. PMID:21681193
  • Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.
    Kim BC, Lee HC, Lee JJ, Choi CM, Kim DK, Lee JC, Ko YG, Lee JS.
    EMBO J. 2012 Nov 14;31(22):4289-303. PMID: 23085987
  • Anti-tumor effect of AlkB homolog 3 knockdown in hormone-independent prostate cancer cells.
    Koike K, Ueda Y, Hase H, Kitae K, Fusamae Y, Masai S, Inagaki T, Saigo Y, Hirasawa S, Nakajima K, Ohshio I, Makino Y, Konishi N, Yamamoto H, Tsujikawa K.
    Curr Cancer Drug Targets. 2012 Sep;12(7):847-56. PMID:22515525
  • Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma.
    Okazaki T, Kageji T, Kuwayama K, Kitazato KT, Mure H, Hara K, Morigaki R, Mizobuchi Y, Matsuzaki K, Nagahiro S.
    Cancer Lett. 2012 Oct 28;323(2):199-207. PMID:22542810
  • D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
    El Sayed SM, Abou El-Magd RM, Shishido Y, Chung SP, Sakai T, Watanabe H, Kagami S, Fukui K.
    Cancer Gene Ther. 2012 Jan;19(1):1-18. PMID:21921941
  • ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and Tweak/Fn14/VEGF signals.
    Shimada K, Fujii T, Anai S, Fujimoto K, Konishi N.
    Clin Cancer Res. 2012 Oct 1;18(19):5247-55. PMID:22850567
  • ZDHHC8 knockdown enhances radiosensitivity and suppresses tumor growth in a mesothelioma mouse model.
    Sudo H, Tsuji AB, Sugyo A, Ogawa Y, Sagara M, Saga T.
    Cancer Sci. 2012 Feb;103(2):203-9. PMID:22017350
  • Therapeutic Potential of SOX2 Inhibition for Embryonal Carcinoma.
    Ushida H, Chano T, Minami K, Kita H, Kawakami T, Okabe H, Okada Y, Okamoto K.
    J Urol. 2012 May;187(5):1876-81. PMID:22425046
  • NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
    Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T.
    Cancer Cell. 2012 Mar 20;21(3):348-61. PMID:22439932
  • Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis.
    Yamahatsu K1, Matsuda Y, Ishiwata T, Uchida E, Naito Z.
    Int J Oncol. 2012 May;40(5):1345-57. PMID: 22246533
  • PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
    Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K, Nakajima Y.
    Cancer Res. 2012 Sep 15;72(18):4829-39. PMID:22826605
  • The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
    Andradas C, Caffarel MM, Pérez-Gómez E, Salazar M, Lorente M, Velasco G, Guzmán M, Sánchez C.
    Oncogene. 2011 Jan 13;30(2):245-52. PMID:20818416 short communication
  • RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.
    Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H.
    Cancer Res. 2011 Jul 1;71(13):4598-607. PMID:21571861
  • GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
    Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H.
    PLoS One. 2011;6(8):e23359. PMID:21858086
  • Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells.
    Kobayashi T, Shimura T, Yajima T, Kubo N, Araki K, Wada W, Tsutsumi S, Suzuki H, Kuwano H, Raz A.
    Clin Exp Metastasis. 2011 Apr;28(4):367-76. PMID:21331750
  • Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action.
    Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Lakatosh SA, Barcia J, Guzmán M, Velasco G.
    Cell Death Cell Death Differ. 2011 Jun;18(6):959-73. PMID:21233844
  • miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.
    Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K.
    Blood. 2011 Dec 22;118(26):6881-92. PMID:22042699
  • ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members.
    Shigematsu S, Fukuda S, Nakayama H, Inoue H, Hiasa Y, Onji M, Higashiyama S.
    Exp Cell Res. 2011 Aug 1;317(13):1851-9. PMID:21624362
  • The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer.
    Takei Y, Takigahira M, Mihara K, Tarumi Y, Yanagihara K.
    Cancer Res. 2011 Feb 15;71(4):1442-1453. PMID:21169410
  • Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model.
    Takigami I, Ohno T, Kitade Y, Hara A, Nagano A, Kawai G, Saitou M, Matsuhashi A, Yamada K, Shimizu K.
    Int J Cancer. 2011 Jan 1;128(1):216-26. PMID:20648560
  • ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
    Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N.
    Br J Cancer. 2011 Feb 15;104(4):700-6. PMID:21285982
  • Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α.
    Tomita S, Ishibashi K, Hashimoto K, Sugino T, Yanagida T, Kushida N, Shishido K, Aikawa K, Sato Y, Suzutani T, Yamaguchi O.
    Cancer Sci. 2011 Jan;102(1):57-63. PMID:21054677
  • miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.
    Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J.
    Cancer Res. 2011 Oct 15;71(20):6450-62. PMID:21868754
  • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.
    Vara D, Salazar M, Olea-Herrero N, Guzmán M, Velasco G, Díaz-Laviada I.
    Cell Death Differ. 2011 Jul;18(7):1099-111. PMID:21475304
  • The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.
    Zeng Y, He Y, Yang F, Mooney S, Getzenberg R, Orban J, Kulkarni P.　
    J Biol Chem. 2011 Apr 22;286(16):13985-94. PMID:21357425
  • Atelocollagen-delivered siRNA targeting the FABP5 gene as an experimental therapy for prostate cancer in mouse xenografts.
    Forootan SS, Bao ZZ, Forootan FS, Kamalian L, Zhang Y, Bee A, Foster CS, Ke Y.
    Int J Oncol. 2010 Jan;36(1):69-76. PMID:19956834
  • Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.
    He L, Ingram A, Rybak AP, Tang D.
    J Clin Invest. 2010 Jun 1;120(6):2094-108. PMID:20458142
  • miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma.
    Liu CJ, Tsai MM, Hung PS, Kao SY, Liu TY, Wu KJ, Chiou SH, Lin SC, Chang KW.
    Cancer Res. 2010 Feb 15;70(4):1635-44. PMID:20145132
  • Cyclin K and cyclin D1b are oncogenic in myeloma cells.
    Marsaud V, Tchakarska G, Andrieux G, Liu JM, Dembele D, Jost B, Wdzieczak-Bakala J, Renoir JM, Sola B.
    Mol Cancer. 2010 May 10;9:103. PMID:20459741
  • EWS/Fli-1 chimeric fusion gene upregulates vascular endothelial growth factor-A.
    Nagano A, Ohno T, Shimizu K, Hara A, Yamamoto T, Kawai G, Saitou M, Takigami I, Matsuhashi A, Yamada K, Takei Y.
    Int J Cancer. 2010 Jun 15;126(12):2790-8. PMID:19642105
  • Combined functional genome survey of therapeutic targets for hepatocellular carcinoma.
    Satow R, Shitashige M, Kanai Y, Takeshita F, Ojima H, Jigami T, Honda K, Kosuge T, Ochiya T, Hirohashi S, Yamada T.
    Clin Cancer Res. 2010 May 1;16(9):2518-28. PMID:20388846
  • Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma.
    Shimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Miyake M, Fujimoto K, Hirao K, Konishi N.
    Cancer Sci. 2010 Jan;101(1):155-60. PMID: 19860843
  • Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth.
    Shitashige M, Satow R, Jigami T, Aoki K, Honda K, Shibata T, Ono M, Hirohashi S, Yamada T.
    Cancer Res. 2010 Jun 15;70(12):5024-33. PMID:20530691
  • Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model.
    Sudo H, Tsuji AB, Sugyo A, Kohda M, Sogawa C, Yoshida C, Harada YN, Hino O, Saga T.
    Genomics. 2010 Apr;95(4):210-6. PMID:20153416
  • Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA.
    Tanooka H, Tatsumi K, Tsuji H, Noda Y, Katsube T, Ishii H, Ootsuyama A, Takeshita F, Ochiya T.
    Cancer Gene Ther. 2010 Jan;17(1):1-10. PMID:19557034
  • beta-catenin small interfering RNA successfully suppressed progression of multiple myeloma in a mouse model.
    Ashihara E, Kawata E, Nakagawa Y, Shimazaski C, Kuroda J, Taniguchi K, Uchiyama H, Tanaka R, Yokota A, Takeuchi M, Kamitsuji Y, Inaba T, Taniwaki M, Kimura S, Maekawa T.
    Clin Cancer Res. 2009 Apr 15;15(8):2731-8. PMID: 19351774
  • Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
    Lorente M, Carracedo A, Torres S, Natali F, Egia A, Hernández-Tiedra S, Salazar M, Blázquez C, Guzmán M, Velasco G.
    Glia. 2009 Oct;57(13):1374-85. PMID:19229996
  • Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
    Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H.
    Oncogene. 2009 Jan 8;28(1):9-19. PMID: 18806831
  • A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
    Shimada K, Nakamura M, Anai S, De Velasco M, Tanaka M, Tsujikawa K, Ouji Y, Konishi N.
    Cancer Res. 2009 Apr 1;69(7):3157-64. PMID:19293182
  • Syndecan-1, a new target molecule involved in progression of androgen-independent prostate cancer.
    Shimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Konishi N.
    Cancer Sci. 2009 Jul;100(7):1248-54. PMID:19432893
  • Functional genome screen for therapeutic targets of osteosarcoma.
    Yamaguchi U, Honda K, Satow R, Kobayashi E, Nakayama R, Ichikawa H, Shoji A, Shitashige M, Masuda M, Kawai A, Chuman H, Iwamoto Y, Hirohashi S, Yamada T.
    Cancer Sci. 2009 Dec;100(12):2268-74. PMID:19725836
  • Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.
    Bernard-Pierrot I, Gruel N, Stransky N, Vincent-Salomon A, Reyal F, Raynal V, Vallot C, Pierron G, Radvanyi F, Delattre O.
    Cancer Res. 2008 Sep 1;68(17):7165-75. PMID:18757432
  • RPN2 gene confers docetaxel resistance in breast cancer.
    Honma K, Iwao-Koizumi K, Takeshita F, Yamamoto Y, Yoshida T, Nishio K, Nagahara S, Kato K, Ochiya T.
    Nat Med. 2008 Sep;14(9):939-48. PMID:18724378
  • A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model.
    Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S.
    Int J Cancer. 2008 Feb 1;122(3):658-63. PMID:17935125
  • ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
    Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, Ushijima M, Mashima T, Seimiya H, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y.
    Cancer Res. 2008 Oct 15;68(20):8547-54. PMID:18922930
  • Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
    Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H.
    BMC Cancer. 2008 Nov 26;8:348. PMID:19036131
  • Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells.
    Ueno Y, Sakurai H, Tsunoda S, Choo MK, Matsuo M, Koizumi K, Saiki I.
    Int J Cancer. 2008 Jul 15;123(2):340-7. PMID:18398842
  • New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer.
    Yamato K, Yamada T, Kizaki M, Ui-Tei K, Natori Y, Fujino M, Nishihara T, Ikeda Y, Nasu Y, Saigo K, Yoshinouchi M.
    Cancer Gene Ther. 2008 Mar;15(3):140-53. PMID:18157144
  • Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.
    Yu D, Sekine E, Fujimori A, Ochiya T, Okayasu R.
    Cancer Sci. 2008 Apr;99(4):810-5. PMID:18377429
  • Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.
    Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.
    Cancer Res. 2007 Oct 15;67(20):9637-42. PMID:17942892
  • Single-injection ornithine decarboxylase-directed antisense therapy using atelocollagen to suppress human cancer growth.
    Nakazawa K, Nemoto T, Hata T, Seyama Y, Nagahara S, Sano A, Itoh H, Nagai Y, Kubota S.
    Cancer. 2007 Mar 1;109(5):993-1002. PMID:17318877
  • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells.
    Tazawa H, Tsuchiya N, Izumiya M, Nakagama H.
    Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7. PMID:17875987
  • Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
    Yamashita M, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F.
    Int J Cancer. 2007 May 15;120(10):2243-50. PMID:17266036
  • Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.
    Fujii T, Saito M, Iwasaki E, Ochiya T, Takei Y, Hayashi S, Ono A, Hirao N, Nakamura M, Kubushiro K, Tsukazaki K, Aoki D.
    Int J Oncol. 2006 Sep;29(3):541-8. PMID:16865269
  • Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma.
    Nozawa H, Tadakuma T, Ono T, Sato M, Hiroi S, Masumoto K, Sato Y.
    Cancer Sci. 2006 Oct;97(10):1115-24. PMID:16984384
  • Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts.
    Takei Y, Kadomatsu K, Goto T, Muramatsu T.
    Cancer. 2006 Aug 15;107(4):864-73. PMID:16832814
  • The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target.
    Kuroda M, Kiyono T, Oikawa K, Yoshida K, Mukai K.
    Br J Cancer. 2005 Jan 31;92(2):290-3. PMID:15655544
  • Morpholino antisense oligomer targeting human midkine: its application for cancer therapy.
    Takei Y, Kadomatsu K, Yuasa K, Sato W, Muramatsu T.
    Int J Cancer. 2005 Apr 10;114(3):490-7. PMID:15578698
  • Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo.
    Minakuchi Y, Takeshita F, Kosaka N, Sasaki H, Yamamoto Y, Kouno M, Honma K, Nagahara S, Hanai K, Sano A, Kato T, Terada M, Ochiya T.
    Nucleic Acids Res. 2004 Jul 22;32(13):e109. PMID:15272050
  • A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics.
    Takei Y, Kadomatsu K, Yuzawa Y, Matsuo S, Muramatsu T.
    Cancer Res. 2004 May 15;64(10):3365-70. PMID:15150085
  • Antisense oligodeoxynucleotide against HST-1/FGF-4 suppresses tumorigenicity of an orthotopic model for human germ cell tumor in nude mice.
    Hirai K, Sasaki H, Sakamoto H, Takeshita F, Asano K, Kubota Y, Ochiya T, Terada M.
    J Gene Med. 2003 Nov;5(11):951-7. PMID:14601132
  • 5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy.
    Takei Y, Kadomatsu K, Itoh H, Sato W, Nakazawa K, Kubota S, Muramatsu T.
    J Biol Chem. 2002 Jun 28;277(26):23800-6. PMID: 11959856
  • Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells.
    Takei Y, Kadomatsu K, Matsuo S, Itoh H, Nakazawa K, Kubota S, Muramatsu T.
    Cancer Res. 2001 Dec 1;61(23):8486-91. PMID:11731432
Orthopedics
  • Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13.
    Miyauchi A, Noguchi M, Lei XF, Sakaki M, Kobayashi-Tanabe M, Haraguchi S, Miyazaki A, Kim-Kaneyama JR.
    Sci Rep. 2023 May 8;13(1):7446. PMID: 37156857.
  • Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles.
    Kitakaze T, Sugihira T, Kameyama H, Maruchi A, Kobayashi Y, Harada N, Yamaji R.
    J Clin Biochem Nutr. 2022 Sep;71(2):112-121. PMID: 36213788.
  • Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis.
    Ito Y, Matsuzaki T, Ayabe F, Mokuda S, Kurimoto R, Matsushima T, Tabata Y, Inotsume M, Tsutsumi H, Liu L, Shinohara M, Tanaka Y, Nakamichi R, Nishida K, Lotz MK, Asahara H.
    Nat Commun. 2021 Jul 6;12(1):4148. PMID: 34230481.
  • MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy.
    Fukuoka M, Fujita H, Numao K, Nakamura Y, Shimizu H, Sekiguchi M, Hohjoh H.
    Commun Biol. 2021 Mar 29;4(1):427. PMID: 33782502.
  • Effect of enhanced aryl hydrocarbon receptor expression on inflammatory response and healing of alveolar bone defects in diabetic rats.
    Luo Yicai, Li Hao.
    Chinese Journal of Tissue Engineering Research, 2021, 25(14): 2166-2171.
  • Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56.
    Kitakaze T, Yoshikawa M, Kobayashi Y, Kimura N, Goshima N, Ishikawa T, Ogata Y, Yamashita Y, Ashida H, Harada N, Yamaji R.
    Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118563. PMID: 31666191
  • ROR2 blockade as a therapy for osteoarthritis.
    Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford JR, Pitzalis C, Aigner T, Corder R, Bertrand J, Dell'Accio F.
    Sci Transl Med. 2020 Sep 16;12(561):eaax3063. PMID: 32938794.
  • Wwp2 maintains cartilage homeostasis through regulation of Adamts5.
    Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H.
    Nat Commun. 2019 Jun 3;10(1):2429. PMID: 31160553
  • Dissociation of Systemic Glucose Homeostasis from Triacylglyceride Accumulation by Reduced Acsl6 Expression in Skeletal Muscle.
    Lee, J.Y., Kim, AR., Jung, YH. et al.
    Biotechnol Bioproc E (2018) 23(4): 465-472.
  • Effects of Co-Transfection with Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein on Skeletal Muscle Growth.
    Od BAYARSAIKHAN, Nobuhiko KAWAI, Hiroyo MORI, Nao KINOUCHI, Takeshi NIKAWA, Eiji TANAKA
    Journal of Oral Health and Biosciences Vol. 30 (2017) No. 1 p. 1-7
  • lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy.
    Neppl RL, Wu CL, Walsh K.
    J Cell Biol. 2017 Nov 6;216(11):3497-3507. PMID: 28855249
  • AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts.
    Kato M, Ospelt C, Kolling C, Shimizu T, Kono M, Yasuda S, Michel BA, Gay RE, Gay S, Klein K, Atsumi T.
    Oncotarget. 2016 Sep 27;7(39):64221-64232. PMID: 27623077
  • Inhibition of microRNA-222 expression accelerates bone healing with enhancement of osteogenesis, chondrogenesis, and angiogenesis in a rat refractory fracture model.
    Yoshizuka M, Nakasa T, Kawanishi Y, Hachisuka S, Furuta T, Miyaki S, Adachi N, Ochi M.
    J Orthop Sci. 2016 Nov;21(6):852-858. PMID: 27545451
  • Lentivirus-TAZ Administration Alleviates Osteoporotic Phenotypes in the Femoral Neck of Ovariectomized Rats.
    Zhang Y, Wang Z, Ding L, Damaolar A, Li Z, Qiu Y, Yin Z.
    Cell Physiol Biochem. 2016;38(1):283-94. PMID: 26800426
  • RasGRP4 is Aberrantly Expressed in the Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis and Controls their Proliferation.
    Kono M, Yasuda S, Stevens RL, Koide H, Kurita T, Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T, Amengual O, Horita T, Shimizu T, Majima T, Koike T, Atsumi T.
    Arthritis Rheumatol. 2015 Feb;67(2):396-407. PMID: 25330932
  • Female-specific regulation of skeletal muscle mass by USP19 in young mice.
    Ogawa M, Kitakaze T, Harada N, Yamaji R.
    J Endocrinol. 2015 Jun;225(3):135-45. PMID: 25901042
  • Acceleration of healing of the medial collateral ligament of the knee by local administration of synthetic microRNA-210 in a rat model.
    Muhammad Sakti, Tomoyuki Nakasa, Takeshi Shoji, Muhammad Andry Usman, Yoshitaka Kawanishi, Michio Hamanishi, Irawan Yusuf, Mitsuo Ochi.
    Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, Volume 2, Issue 4, October 2015, Pages 129-136.
  • The effect of administration of double stranded MicroRNA-210 on acceleration of Achilles tendon healing in a rat model.
    Usman MA, Nakasa T, Shoji T, Kato T, Kawanishi Y, Hamanishi M, Kamei N, Ochi M.
    J Orthop Sci. 2015 May;20(3):538-46. PMID: 25753838
  • The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity.
    Bobadilla M, Sáinz N, Abizanda G, Orbe J, Rodríguez JA, Páramo JA, Prósper F, Pérez-Ruiz A.
    Stem Cells Dev. 2014 Jun 15;23(12):1417-27. PMID: 24548137
  • Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model.
    Kawanishi Y, Nakasa T, Shoji T, Hamanishi M, Shimizu R, Kamei N, Usman M, Ochi M.
    Arthritis Res Ther. 2014 Nov 28;16(6):488. PMID: 25430980
  • Local Applications of Myostatin-siRNA with Atelocollagen Increase Skeletal Muscle Mass and Recovery of Muscle Function.
    Kawakami E, Kawai N, Kinouchi N, Mori H, Ohsawa Y, Ishimaru N, Sunada Y, Noji S, Tanaka E.
    PLoS One. 2013 May 22;8(5):e64719.PMID: 23717655　　
  • A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization.
    Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Kuroda R, Akimaru H, Mifune Y, Shoji T, Fukui T, Asahi M, Kurosaka M, Asahara T.
    Lab Invest. 2013 Sep;93(9):1036-53. PMID: 23897412
  • Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and Osterix.
    Yang D, Okamura H, Nakashima Y, Haneji T.
    J Biol Chem. 2013 Nov 22;288(47):33530-41. PMID: 24106268
  • The Effect of Intra-articular Injection of MicroRNA-210 on Ligament Healing in a Rat Model.
    Shoji T, Nakasa T, Yamasaki K, Kodama A, Miyaki S, Niimoto T, Okuhara A, Kamei N, Adachi N, Ochi M.
    Am J Sports Med. 2012 Nov;40(11):2470-8. PMID: 22986296
  • Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model.
    Nakasa T, Ishikawa M, Shi M, Shibuya H, Adachi N, Ochi M.
    J Cell Mol Med. 2010 Oct;14(10):2495-505. PMID:19754672
  • Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
    Ono Y, Gnocchi VF, Zammit PS, Nagatomi R.
    J Cell Sci. 2009 Dec 15;122(Pt 24):4427-38. PMID: 19920078
  • Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a.
    Nagata Y, Nakasa T, Mochizuki Y, Ishikawa M, Miyaki S, Shibuya H, Yamasaki K, Adachi N, Asahara H, Ochi M.
    Arthritis Rheum. 2009 Sep;60(9):2677-83. PMID:19714650

Dermatology
  • MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
    Pickup ME, Hu A, Patel HJ, Ahmed MI.
    J Invest Dermatol. 2023 Mar;143(3):480-491.e5. PMID: 36116511.
  • The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts.
    Ikawa T, Ichimura Y, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    J Invest Dermatol. 2022 Jun;142(6):1541-1551.e3. PMID: 34838790.
  • Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis.
    Sawamura S, Makino K, Ide M, Shimada S, Kajihara I, Makino T, Jinnin M, Fukushima S.
    Int J Mol Sci. 2022 Jun 18;23(12):6811. PMID: 35743254.
  • Endothelial CCR6 expression due to FLI1 deficiency contributes to vasculopathy associated with systemic sclerosis.
    Ikawa T, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    Arthritis Res Ther. 2021 Nov 13;23(1):283. PMID: 34774095
  • TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
    Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW.
    Nat Commun. 2021 Jul 20;12(1):4404. PMID: 34285225
  • TGFβ-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis.
    Dees C, Pötter S, Zhang Y, Bergmann C, Zhou X, Luber M, Wohlfahrt T, Karouzakis E, Ramming A, Gelse K, Yoshimura A, Jaenisch R, Distler O, Schett G, Distler JH.
    J Clin Invest. 2020 May 1;130(5):2347-2363. PMID: 31990678
  • Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells via retinoic acid-mediated regulatory T cell induction: A role in scleroderma.
    Miura S, Asano Y, Saigusa R, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Sato S, Kadono T.
    J Dermatol Sci. 2020 Feb;97(2):125-134. PMID: 31959382
  • Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis.
    Dosoki H, Stegemann A, Taha M, Schnittler H, Luger TA, Schröder K, Distler JH, Kerkhoff C, Böhm M.
    Exp Dermatol. 2017 Jan;26(1):73-81. PMID: 27576129
  • Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.
    Tomcik M, Palumbo-Zerr K, Zerr P, Sumova B, Avouac J, Dees C, Distler A, Becvar R, Distler O, Schett G, Senolt L, Distler JH.
    Ann Rheum Dis. 2016 Mar;75(3):609-16. PMID: 25603829
  • Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling.
    Distler A, Ziemer C, Beyer C, Lin NY, Chen CW, Palumbo-Zerr K, Dees C, Weidemann A, Distler O, Schett G, Distler JH.
    Ann Rheum Dis. 2014 Mar 1;73(3):624-7. PMID: 24257024
  • Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling.
    Distler A, Deloch L, Huang J, Dees C, Lin NY, Palumbo-Zerr K, Beyer C, Weidemann A, Distler O, Schett G, Distler JH.
    Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. PMID: 23148305
  • Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
    Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, Zerr P, Akhmetshina A, Ruat M, Distler O, Beyer C, Schett G, Distler JH.
    Ann Rheum Dis 2012;71:785-789 PMID:22402139
  • Inhibition of sumoylation prevents experimental fibrosis.
    Khodzhigorova A, Akhmetshina A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH.
    Ann Rheum Dis. 2012 Nov;71(11):1904-8. PMID:22904261

Cardioangiology
  • Endogenous Interleukin-1β Is Implicated in Intraplaque Hemorrhage in Apolipoprotein E Gene Null Mice.
    Suzuki E, Imuta H, Fujita D, Takahashi M, Oba S, Kiyosue A, Nishimatsu H.
    Circ J. 2018 Mar 23;82(4):1130-1138. PMID: 29467356
  • Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.
    Orriols M, Varona S, Martí-Pàmies I, Galán M, Guadall A, Escudero JR, Martín-Ventura JL, Camacho M, Vila L, Martínez-González J, Rodríguez C.
    Cardiovasc Res. 2016 Jun 1;110(3):431-42. PMID: 27089918
  • Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.
    Gomez-Rodriguez V, Orbe J, Martinez-Aguilar E, Rodriguez JA, Fernandez-Alonso L, Serneels J, Bobadilla M, Perez-Ruiz A, Collantes M, Mazzone M, Paramo JA, Roncal C.
    FASEB J. 2015 Mar;29(3):960-72. PMID: 25414484
  • Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure.
    Miyachi H, Mii S, Enomoto A, Murakumo Y, Kato T, Asai N, Komori K, Takahashi M.
    J Vasc Surg. 2014 Aug;60(2):479-489.e5. PMID: 23948670
  • Inhibition of Neuregulin-1/ErbB Signaling in the Rostral Ventrolateral Medulla Leads to Hypertension through Reduced Nitric Oxide Synthesis
    Matsukawa R, Hirooka Y, Ito K, Sunagawa K.
    Am J Hypertens. 2013 Jan;26(1):51-7. PMID: 23382327
  • Neuregulin-1/ErbB signaling in rostral ventrolateral medulla is involved in blood pressure regulation as an antihypertensive system.
    Matsukawa R, Hirooka Y, Nishihara M, Ito K, Sunagawa K.
    J Hypertens. 2011 Sep;29(9):1735-42. PMID:21738056
  • Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts.
    Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K.
    J Vasc Surg. 2006 Sep;44(3):633-41. PMID:16950446
  • Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats.
    Shinozaki K, Nishio Y, Yoshida Y, Koya D, Ayajiki K, Masada M, Kashiwagi A, Okamura T.
    J Cardiovasc Pharmacol. 2005 Oct;46(4):505-12. PMID:16160605

Neurology
  • Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.
    Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.
    J Neurochem. 2019 Feb;148(3):373-385. PMID: 30295925
  • Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury.
    Chen HP, Zhou W, Kang LM, Yan H, Zhang L, Xu BH, Cai WH.
    Neurochem Res. 2014 Jan;39(1):76-83. PMID: 24234845
  • Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
    Takeuchi K, Yoshioka N, Higa Onaga S, Watanabe Y, Miyata S, Wada Y, Kudo C, Okada M, Ohko K, Oda K, Sato T, Yokoyama M, Matsushita N, Nakamura M, Okano H, Sakimura K, Kawano H, Kitagawa H, Igarashi M.
    Nat Commun. 2013;4:2740. PMID: 24220492
  • Photomechanical Wave-Driven Delivery of siRNAs Targeting Intermediate Filament Proteins Promotes Functional Recovery after Spinal Cord Injury in Rats
    Takahiro Ando, Shunichi Sato mail, Terushige Toyooka, Hiroaki Kobayashi, Hiroshi Nawashiro, Hiroshi Ashida, Minoru Obara.
    PLoS One. 2012;7(12):e51744. PMID: 20181596
  • Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats.
    Toyooka T, Nawashiro H, Shinomiya N, Shima K.
    J Neurotrauma. 2011 Apr;28(4):607-18. PMID:21250919
  • An siRNA against JC virus (JCV) agnoprotein inhibits JCV infection in JCV-producing cells inoculated in nude mice.
    Matoba T, Orba Y, Suzuki T, Makino Y, Shichinohe H, Kuroda S, Ochiya T, Itoh H, Tanaka S, Nagashima K, Sawa H.
    Neuropathology. 2008 Jun;28(3):286-94. PMID:18179406

Miscellaneous
  • Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells.
    Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S.
    Exp Mol Med. 2022 Jan;54(1):81-90. PMID: 35079118.
  • The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.
    Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y.
    Commun Biol. 2020 Jan 16;3(1):30. PMID: 31949279
  • Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats.
    Li H, Zhong X, Chen Z, Li W.
    J Orthop Surg Res. 2019 May 30;14(1):167. PMID: 31146750
  • Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein β degradation by adenosine receptor A1.
    Mitani T, Watanabe S, Yoshioka Y, Katayama S, Nakamura S, Ashida H.
    Biochim Biophys Acta. 2017 Sep 28;1864(12):2438-2448. PMID: 28965824
  • PACAP suppresses dry eye signs by stimulating tear secretion.
    Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
    Nat Commun. 2016 Jun 27;7:12034. PMID: 27345595
  • Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.
    Chelakkot-Govindalayathil AL, Mifuji-Moroka R, D'Alessandro-Gabazza CN, Toda M, Matsuda Y, Gil-Bernabe P, Roeen Z, Yasuma T, Yano Y, Gabazza EC, Iwasa M, Takei Y.
    J Thromb Haemost. 2015 Jan;13(1):142-54. PMID: 25399514
  • Attenuated AMH signaling pathway plays an important role in the pathogenesis of ovarian hyperstimulation syndrome.
    Wang L, Li H, Ai J, Yue J, Li Z, Zhang H, Zhao Y.
    Am J Transl Res. 2015 Oct 15;7(10):1925-38.
  • A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.
    Ashrin MN, Arakaki R, Yamada A, Kondo T, Kurosawa M, Kudo Y, Watanabe M, Ichikawa T, Hayashi Y, Ishimaru N.
    J Immunol. 2014 May 1;192(9):4025-31. PMID: 24670797
  • Osteopontin knockdown in the kidneys of hyperoxaluric rats leads to reduction in renal calcium oxalate crystal deposition.
    Tsuji H, Shimizu N, Nozawa M, Umekawa T, Yoshimura K, De Velasco MA, Uemura H, Khan SR.
    Urolithiasis. 2014 Jun;42(3):195-202. PMID: 24619192
  • Regulation of mucosal mast cell activation by short interfering RNAs targeting syntaxin4.
    Liu S, Nugroho AE, Shudou M, Maeyama K.
    Immunol Cell Biol. 2012 Mar;90(3):337-45. PMID:21625250
  • Targeted suppression of HO-2 gene expression impairs the innate anti-inflammatory and repair responses of the cornea to injury.
    Bellner L, Patil KA, Castellano K, Halilovic A, Dunn MW, Schwartzman ML.
    Mol Vis. 2011 Apr 29;17:1144-52. PMID:21552471
  • A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice.
    Watanabe M, Ishimaru N, Ashrin MN, Arakaki R, Yamada A, Ichikawa T, Hayashi Y.
    PLoS One. 2011 Apr 22;6(4):e19017. PMID:21544193
  • Targeted conversion of the transthyretin gene in vitro and in vivo.
    Nakamura M, Ando Y, Nagahara S, Sano A, Ochiya T, Maeda S, Kawaji T, Ogawa M, Hirata A, Terazaki H, Haraoka K, Tanihara H, Ueda M, Uchino M, Yamamura K.
    Gene Ther. 2004 May;11(10):838-46. PMID:14961068
  • Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines.
    Ochiya T, Nagahara S, Sano A, Itoh H, Terada M.
    Curr Gene Ther. 2001 May;1(1):31-52. PMID:12109137