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A variety of unlabeled / labeled plant lectins for glycan research

Introduction

Lectins help identify, bind and activate glycans. Sugar chains are said to be the third life chain following nucleic acids and proteins, and are widely involved in human life phenomena. For example, it is involved in ABO blood group determination, influenza infection, and diseases such as cancer. MGC WoodChem can manufacture lectins, a tool for sugar chain research, from biomass raw materials. We also provide products that enable researchers to study sugar chains more easily.

What are Lectins?

A lectin is defined by Goldstein* et al.

A carbohydrate-binding protein or glycoprotein, other than the product of an immune response, that aggregates cells or glycoconjugates.
It has two or more binding sites and can aggregate animal and plant cells.
Aggregation is specifically blocked by mono- or oligosaccharides. Lectin is generally used as a general term for substances with specific sugar binding activity among proteins or glycoproteins present in plants, animals, microorganisms, etc.

Lectins have been applied to the detection and analysis of glycoconjugates for a long time, and are one of the tools that are active in research in the field of glycoscience.

MGC Woodchem offers lectins with various specificities. In addition to research use, we also supply customized lectins for specific applications.

Aiming to expand the practical use of lectins, we have decided to transfer the development and manufacturing of lectins to our parent company, Mitsubishi Gas Chemical, from April 2023. MGC Woodchem will continue to sell.

* Goldstein,IJ,Hughes,RC,Monsigny,M.,Osawa,T.,and Sharon,N.,Nature.285,66 (1980)

What are sugar chains?

A sugar chain is a group of compounds in which various sugars are linked by glycosidic bonds. Glycans are attached to proteins and fats and are present on the cell surface.

MGC WoodChem provides labeling kits that enable easy analysis of the types of monosaccharides that make up sugar chains.

Product lineup - Ordering Information

Catalog Number	Product Name	Size
MGC-J102	Agaricus bisporus [ABA] Lectin	5 mg
MGC-J202	Agaricus bisporus [ABA] Lectin (Biotin conjugated)	1 mg
MGC-J101-R	Aleuria aurantia [AAL] Lectin	1 mg
MGC-J201-R	Aleuria aurantia [AAL] Lectin (Biotin conjugated)	1 mg
MGC-J121	Anti-H Lectin	8 ml
MGC-J122	Anti-H Strong Lectin	2 ml
MGC-J114	Arachis hypogaea (peanut) [PNA] Lectin	5 mg
MGC-J214	Arachis hypogaea (peanut) [PNA] Lectin (Biotin conjugated)	1 mg
MGC-J203	Canavalia ensiformis (jack bean) [Con A] Lectin	1 mg
MGC-J105	Datura stramonium [DSA] Lectin	5 mg
MGC-J205	Datura stramonium [DSA] Lectin (Biotin conjugated)	1 mg
MGC-J104	Dolichos biflorus [DBA] Lectin	5 mg
MGC-J204	Dolichos biflorus [DBA] Lectin (Biotin conjugated)	1 mg
MGC-J106	Erythrina cristagalli [ECA] Lectin	5 mg
MGC-J206	Erythrina cristagalli [ECA] Lectin (Biotin conjugated)	1 mg
MGC-J117	Glycine max (soybean) [SBA] Lectin	5 mg
MGC-J217	Glycine max (soybean) [SBA] Lectin (Biotin conjugated)	1 mg
MGC-J107	Lens culinaris [LCA] Lectin	5 mg
MGC-J207	Lens culinaris [LCA] Lectin (Biotin conjugated)	1 mg
MGC-J109	Lotus tetragonolobus [Lotus] Lectin	5 mg
MGC-J209	Lotus tetragonolobus [Lotus] Lectin (Biotin conjugated)	1 mg
MGC-J110	Maackia amurensis [MAM] Lectin	2 mg
MGC-J210	Maackia amurensis [MAM] Lectin (Biotin conjugated)	1 mg
MGC-J211	Phaseolus vulgaris [PHA-E4] Lectin	1 mg
MGC-J212	Phaseolus vulgaris [PHA-L4] Lectin	1 mg
MGC-J113	Phaseolus vulgaris [PHA-P] Lectin	5 mg
MGC-J116	Phytolacca americana [PWM] Lectin	5 mg
MGC-J115	Pisum sativum [PSA] Lectin	5 mg
MGC-J118	Sambucus sieboldiana [SSA] Lectin	5 mg
MGC-J218	Sambucus sieboldiana [SSA] Lectin (Biotin conjugated)	1 mg
MGC-J120	Triticum vulgare [WGA] Lectin	5 mg
MGC-J220	Triticum vulgare [WGA] Lectin (Biotin conjugated)	1 mg
MGC-J119	Ulex europaeus [UEA-I] Lectin	2 mg

Availability of Lectins

Combined classification ^{* 1}	Lectin abbreviation	Origin	Combined classification ^{* 1}	Label	Label	Immobilization
Monosaccharide			Sugar chain type ^{* 2}	Unlabeled	Biotin	Agarose
Gal / GalNAc specific	ABA	Agaricus bisporus	O	Yes	Yes	No
		mushrooms
	DBA	Dolichos biflorus	O GL	Yes	Yes	No
		Dolichos
	ECA	Erythrina cristagalli Erythrina	NO GL	Yes	Yes	No
		cristagalli
	PHA-E4	Phaseolus vulgaris	N	Yes	Yes	No
		green beans
	PHA-L4	Phaseolus vulgaris	N	Yes	Yes	No
		green beans
	PHA-P	Phaseolus vulgaris	N	Yes	No	No
		green beans
	PNA	Arachis hypogaea	O GL	Yes	Yes	No
		peanuts
	SBA	Glycine max	O GL	Yes	Yes	No
		soybean
Man specific	Con A	Canavalia ensiformis	N	Yes	Yes	No
		Concanavalin A
	LCA	Lens culinaris	N	Yes	Yes	No
		Lentils
	PSA	Pisum sativum	N	Yes	No	No
		peas
Fuc specific	AAL	Aleuria aurantia Heero	NO GL	Yes	Yes	No
		Chawantake
	Lotus	Lotus tetragonolobus	O GL	Yes	Yes	No
		Lotus
	UEA-I	Ulex europaeus	O GL	Yes	Yes	No
		Gorse
GlcNAc specific	DSA	Datura stramonium	N GL	Yes	Yes	No
		Datura
	PWM	Phytolacca americana	N	Yes	No	No
		Pokeweed
	WGA	Triticum vulgaris	N	Yes	Yes	Yes
		wheat germ
Sialic acid specific	SSA	Sambucus sieboldiana	NO	Yes	Yes	Yes
		Japanese elderberry
Sialic acid specific	MAM	Maackia amurensis Maackia	NO	Yes	Yes	No
		amurensis

* 1 This is a classification for convenience, and does not guarantee the binding or non-binding of all sugars and sugar chains.
* 2 Glycan type N: N type sugar chain, O: O type sugar chain, GL: Glycolipid sugar chain