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Brochures / Flyers
Chemical modification
of glyco-protein
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Conjugation reaction
of glycan with amine
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Fushimi Pharmaceuticals Website (external site)
http://www.fushimi.co.jp/en/industrial-chemicals/industrial-chemicals-06.html

TRANSGLYCOSYLATION PEPTIDES/ PROTEINS
transglycosylation.JPG
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New Synthesis Method 
Sugar-Peptides, Sugar-Nucleotides
newsynthesis.JPG
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Fushimi Pharmaceuticals (FSP) Products Dashboard Glycan-related products - Industrial Chemicals

Product Lineup

  • SGP（α2,6-SGP）
  • α2,3-SGP
  • Asialo-SGP
  • SG
  • Asialoglycan
  • Agalactoglycan
  • SG-Oxazoline
  • G2-Oxazoline
  • G0-Oxazoline
  • CDMBI
TRANSGLYCOSYLATION PEPTIDES/ PROTEINS
transglycosylation.JPG
PDF Download

New Synthesis Method 
Sugar-Peptides, Sugar-Nucleotides
newsynthesis.JPG
PDF Download

 

All Products  

Catalog Number Product Name Size  Structure
FSP-171801 Sialylglycopeptide (SGP)

■Formula，Molecular Weight:
C112H189N15O70, 2,865.76
■Assay:min. 95% (HPLC)

It is well known that the synthesis of structurally homogeneous carbohydrate chain is difficult due to various types of glycoside bonding. On the other hand, egg yolk is known to contain a glycopeptide with homogeneous structure. The main component is SGP. Fushimi Pharmaceutical Co. has succeeded in producing chicken egg SGP having homogeneous structure in a large quantity at low production cost. Their hope is this will open various opportunities to develop new bio-pharmaceuticals and bio-anallytical reagents. 		  10 mg
 FSP-171803   alpha 2,3-Sialylglycopeptide (alpha 2,3-SGP)

■Formula，Molecular Weight:
C112H189N15O70, 2,865.76

■Assay:min. 95% (HPLC)

  1 mg  
 FSP-171804  Asialoglycopeptide (Asialo-SGP)

■Formula，Molecular Weight:
C90H155N13O54, 2,283.25
■Assay:min. 95% (HPLC)



  1 mg  
 FSP-171816  Agalactoglycopeptide (Agalacto-SGP)

■Formula，Molecular Weight:
C78H135N13O44, 1,958.97
■Assay:min. 95% (HPLC)		  1 mg  

 

 

 

 
Catalog Number Product Name Size  Structure
FSP-171808 alpha 2,6-Sialylglycan (alpha 2,6-SG)

■Formula，Molecular Weight:
C76H125N5O57, 2,020.80
■Assay:min. 95% (HPLC)

 10 mg  
FSP-171817 Asialoglycan (G2-Glycan)

■Formula，Molecular Weight:
C54H91N3O41, 1,438.30
■Assay:min. 95% (HPLC)

 1 mg
FSP-171818 Agalactoglycan (G0-Glycan)

■Formula，Molecular Weight:
C42H71N3O31, 1,114.01
■Assay:min. 95% (HPLC)

 1 mg
FSP-171810 Sialyglycan-Oxazoline (SG-Oxazoline (SG-Oxa))

■Formula，Molecular Weight:
C76H123N5O56, 2,002.79
■Assay:min. 95% (HPLC)

 1 mg  
FSP-171814 Asialoglycan-Oxazoline (G2-Oxazoline (G2-Oxa), Asialo-Oxazoline)

■Formula，Molecular Weight:
C54H89N3O40, 1,420.28
■Assay:min. 95% (HPLC)

 1 mg  
FSP-171815 Agalactoglycan-Oxazoline (G0-Oxazoline (G0-Oxa), Agalacto-Oxazoline)

■Formula，Molecular Weight:
C42H69N3O30, 1,096.00
■Assay:min. 95% (HPLC)

 1 mg  

ENGase

Catalog Number Product Name Size
FSP-171831 Endo-CC (Wild Type)

■Source:Endo-CC recombinant from Coprinopsis cinerea is expressed in E.coli as a fusion to His tag.
■Unit Definition:One unit is defined as the amount of enzyme that produce 1μmol SG from SGP per minute at 37℃, pH 8.0.

 300 munits
FSP-171832 Endo-CC N180H (Mutant)

■Source:Endo-CC N180H recombinant from Coprinopsis cinerea is expressed in E.coli as a fusion to His tag.
■Unit Definition:One unit is defined as the amount of enzyme that produce 1μmol SG-GlcNAc-pNP from pNP-GlcNAc per minute at 30˚C, pH7.5.

 300 munits
Catalog Number Product Name Size  Structure
FSP-171811 CDMBI

■Product Name:CDMBI
2-Chloro-1,3-dimethyl-1H-benzimidazol-3-ium chloride
■Formula，Molecular Weight:
C9H10ClN2Cl, 217.10
■Assay:min. 95% (NMR)

 1 g
Catalog Number Product Name Size  Structure
FSP-171813 Fmoc-Asn-4Sialylglycan (Fmoc-4SGN) 1 mg

Publications

1) Ashida H, Fujimoto T, Kurihara S, Nakamura M, Komeno M, Huang Y, Katayama T, Kinoshita T, Takegawa K:

1,6-α-L-Fucosidases from Bifidobacterium longum subsp. infantis ATCC 15697 involved in the degradation of core-fucosylated N-glycan.
Journal of Applied Glycoscience 67, 23-29 (2020)
DOI:10.5458/jag.jag.JAG-2019_0016

2) Seki H, Huang Y, Arakawa T, Yamada C, Kinoshita T, Iwamoto S, Higuchi Y, Takegawa K, Fushinobu S:

Structural basis for the specific cleavage of core-fucosylated N-glycans by endo-β-N-acetylglucosaminidase from the fungus Cordyceps militaris.
J Biol Chem. 294, 17143-17154 (2019)
PMID:31548313 DOI:10.1074/jbc.RA119.010842

3) Manabe S, Yamaguchi Y, Matsumoto K, Fuchigami H, Kawase T, Hirose K, Mitani A, Sumiyoshi W, Kinoshita T, Abe J, Yasunaga M, Matsumura Y, Ito Y:

Characterization of antibody products obtained through enzymatic and nonenzymatic glycosylation reactions with a glycan oxazoline and preparation of a homogeneous antibody-drug conjugate via Fc N-glycan.
Bioconjug Chem.30, 1343-1355 (2019)
PMID:30938513 DOI:10.1021/acs.bioconjchem.9b00132

4) Huang Y, Higuchi Y, Kinoshita T, Mitani A, Eshima Y, Takegawa K:

Characterization of novel endo-β-N-acetylglucosaminidases from Sphingobacterium species, Beauveria bassiana and Cordyceps militaris that specifically hydrolyze fucose-containing oligosaccharides and human IgG.
Sci. Rep. 8, 246 (2018)
PMID:29321565 DOI:10.1038/s41598-017-17467-y.

5) Higuchi Y, Eshima Y, Huang Y, Kinoshita T, Sumiyoshi W, Nakakita S, Takegawa K:

Highly efficient transglycosylation of sialo-complex-type oligosaccharide using Coprinopsis cinerea endoglycosidase and sugar oxazoline.
Biotechnol. Lett.39, 157-162 (2017)
PMID:27714557 DOI:10.1007/s10529-016-2230-0

6) Suda M, Sumiyoshi W, Kinoshita T, Ohno S:

Reaction of sugar oxazolines with primary amines
Tetrahedron Letters 57, 5446–5448 (2016)
DOI:10.1016/j.tetlet.2016.10.074

7) Eshima Y, Higuchi Y, Kinoshita T, Nakakita S, Takegawa K:

Transglycosylation activity of glycosynthase mutants of endo-β-N-acetylglucosaminidase from Coprinopsis cinerea.
PLoS ONE 10, e0132859 (2015)
PMID:26197478 DOI:10.1371/journal.pone.0132859